PPP1R27 and GCC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPP1R27	GCC1
Description		protein phosphatase 1 regulatory subunit 27	GRIP and coiled-coil domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Golgi Trans Cisterna Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Phosphatase Binding	Protein Binding Small GTPase Binding
	Biological Process
Pathways			Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS			Feeling worry ( 29500382) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Medication adherence in chronic diseases ( 25317111) Refractive error ( 32231278) Type 2 diabetes ( 22158537 26818947 30718926)
Interacting Genes		9 interacting genes: DDIT4L GCC1 KRT34 MVB12A NTAQ1 PPP1CA PPP1CB RPL9 SMCP	66 interacting genes: ABI2 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC33 CCDC85B CEP57 CEP70 COIL CPSF7 DISC1 DNAJA3 DRC4 FAM83A FBF1 FBXO28 FIGNL1 FOSL1 GLI1 GOLGA2 GTF2I HDX ICA1L IKBKG ITSN1 KATNAL1 KDM1A KIAA0753 KIAA1217 KIF5B LCA5 LZTS2 MCRS1 MED4 MEOX1 MID2 NAB2 NAV1 NECAB2 NINL OIP5 PAK5 PPP1R18 PPP1R27 PRPF18 RUNX1 SMARCA2 SMARCD1 SPOP TFIP11 TLE5 TP53BP2 TRIM29 TRIM50 TSC1 USHBP1 UTP14C XIAP ZC4H2 ZFP90 ZNF276
Entrez ID		116729	79571
HPRD ID		17334	07599
Ensembl ID		ENSG00000182676	ENSG00000179562
Uniprot IDs		Q86WC6	A4D0Z4 Q96CN9
PDB IDs
Enriched GO Terms of Interacting Partners?		PTW/PP1 Phosphatase Complex Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Circadian Regulation Of Gene Expression Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Myosin-light-chain-phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Phosphatase Activity Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Virus Maturation Regulation Of Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Positive Regulation Of Termination Of DNA-templated Transcription Dephosphorylation Positive Regulation Of Termination Of RNA Polymerase II Transcription Circadian Rhythm Myosin Phosphatase Activity Phosphoprotein Phosphatase Activity Glycogen Granule RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Energy Derivation By Oxidation Of Organic Compounds Chromosome, Telomeric Region Golgi Trans Cisterna Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Cytoplasm Double-strand Break Repair Via Alternative Nonhomologous End Joining Penetration Of Zona Pellucida Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cytosol ESCRT I Complex	Identical Protein Binding Protein Binding Cytoskeleton Microtubule Centrosome Microtubule Severing Transcription Coactivator Activity Microtubule-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of DNA Repair Microtubule Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process P53 Binding Microtubule Severing ATPase Activity Regulation Of Primary Metabolic Process Lens Fiber Cell Morphogenesis Ciliary Basal Body Regulation Of Cellular Response To Stress Regulation Of Double-strand Break Repair Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Manganese Ion Spindle Pole Cytoplasm Organization Microtubule Cytoskeleton Organization Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Spermatid Development
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