ACSF2 and DGAT2L6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACSF2	DGAT2L6
Description		acyl-CoA synthetase family member 2	diacylglycerol O-acyltransferase 2 like 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Medium-chain Fatty Acid-CoA Ligase Activity	Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process	Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Acylglycerol Acyl-chain Remodeling
Pathways		Mitochondrial Fatty Acid Beta-Oxidation	Acyl chain remodeling of DAG and TAG
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)
Interacting Genes		19 interacting genes: AGTRAP APOA5 APOC1 ARL13B ARL6IP1 C10orf67 CLEC10A CMTM5 COQ9 CREB3 DGAT2L6 GPR152 MICOS13 RDH10 RHBDD2 SENP2 SIGLEC12 SYNGR3 USP40	45 interacting genes: ABHD4 ABHD5 ACSF2 AQP6 ARFIP2 BNIP2 CIAO2A DIABLO ECPAS FARS2 FBXL19 FCER1G GAD2 GPR152 HSD17B11 MCEMP1 MPP1 MTERF4 MYG1 NAPB NDRG4 PBX3 PGRMC2 PITPNC1 REEP4 RNF144A RNF5 RUSF1 SCAND1 SCN3B SLC10A1 SLC10A6 SMG9 SNX4 STAR THAP4 TMED8 TMEM143 TMEM14B TMEM255B TMEM31 TMX2 TTPA TUFM WIPI2
Entrez ID		80221	347516
HPRD ID		13380	13141
Ensembl ID		ENSG00000167107	ENSG00000184210
Uniprot IDs		B4DTB9 E9PF16 Q96CM8	Q6ZPD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylcholine-sterol O-acyltransferase Activator Activity Very-low-density Lipoprotein Particle Clearance Acylglycerol Metabolic Process Chylomicron Neutral Lipid Metabolic Process Phospholipid Efflux Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Regulation Of Ketone Metabolic Process Plasma Lipoprotein Particle Clearance Acylglycerol Homeostasis Protein-containing Complex Remodeling Lipoprotein Metabolic Process Phosphatidylcholine Binding Cholesterol Efflux Triglyceride Homeostasis Regulation Of Triglyceride Metabolic Process Plasma Lipoprotein Particle Remodeling Negative Regulation Of Phosphatidylcholine Catabolic Process Endoplasmic Reticulum Membrane Positive Regulation Of Deacetylase Activity Isoprenoid Binding Primary Lung Bud Formation Positive Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Catabolic Process Triglyceride Metabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Lipase Activator Activity Endoplasmic Reticulum Unfolded Protein Response Cholesterol Transport Regulation Of Phosphatidylcholine Catabolic Process Membrane Lipoprotein Particle Receptor Binding Lipoprotein Lipase Activator Activity Receptor Localization To Non-motile Cilium Acylglycerol Acyl-chain Remodeling Sterol Transport Alcohol Metabolic Process
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