ACSM1 and MAGEA2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ACSM1	MAGEA2
Name		acyl-CoA synthetase medium chain family member 1	MAGE family member A2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Exosome Blood Microparticle	Nucleus PML Body
	Molecular Function	Nucleotide Binding Fatty-acyl-CoA Synthase Activity Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding GTP Binding Fatty Acid Ligase Activity CoA-ligase Activity Ligase Activity Acid-thiol Ligase Activity Benzoate-CoA Ligase Activity Medium-chain Fatty Acid-CoA Ligase Activity Metal Ion Binding Decanoate-CoA Ligase Activity	Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Xenobiotic Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Benzoate Metabolic Process Fatty Acid Oxidation Butyrate Metabolic Process Cholesterol Homeostasis	Negative Regulation Of Transcription By RNA Polymerase II Protein Catabolic Process Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction By P53 Class Mediator Cellular Senescence Negative Regulation Of Protein Acetylation
Pathways		Conjugation of benzoate with glycine Conjugation of phenylacetate with glutamine	None
GWAS		Prudent dietary pattern ( 28644415 ) Schizophrenia ( 18347602 20185149 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: CMTM5 MAGEA2 MAGEA2B MTUS2 OSBPL3	21 interacting genes: ACSM1 ANKRD45 BEX1 BEX2 CCDC185 CEP57 COQ4 COX7C DYNLRB1 MBD3 MDM2 NTAQ1 P4HA3 PHKG2 POLL PSMC1 SEPTIN5 SMARCD1 TNIP3 TP53 TRIM28
Entrez ID		116285	4101
HPRD ID		12551	02165
Ensembl ID		ENSG00000166743	ENSG00000268606
Uniprot IDs		B2RAP4 Q08AH1	P43356
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Protein Acetylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Sumoylation Regulation Of Ubiquitin-protein Transferase Activity Cellular Senescence Negative Regulation Of Post-translational Protein Modification Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination PML Body Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding DNA-binding Transcription Factor Binding Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Sterol Transfer Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Filopodium Tip Perinuclear Endoplasmic Reticulum Bile Acid Biosynthetic Process Negative Regulation Of Myoblast Differentiation Bile Acid Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Protein Catabolic Process Regulation Of Protein Modification Process	Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Antibiotic Response To UV-C Protein-containing Complex SUMO Transferase Activity