DRC10 and TACC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DRC10	TACC3
Description		dynein regulatory complex subunit 10	transforming acidic coiled-coil containing protein 3
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium Motile Cilium Ciliary Basal Body Cell Projection	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body Mitotic Spindle
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Nuclear Migration Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis
Pathways			NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Bladder cancer ( 20972438 24163127) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Mean spheric corpuscular volume ( 32888494) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)
Interacting Genes		1 interacting genes: TACC3	30 interacting genes: AKAP9 ARHGDIG ARNT ARNT2 ASPSCR1 AURKA BEX2 BEX3 CATSPERT CCHCR1 CDC20B CDKL5 CIB3 CLIP4 DRC10 EIF3C GDF15 KAT2A KIZ KLC1 KLHL38 NDEL1 NOD2 NUP54 RNF20 SNX20 SPATA18 TBC1D22B TTF2 VPS37C
Entrez ID		115811	10460
HPRD ID		13744	05601
Ensembl ID		ENSG00000166578	ENSG00000013810
Uniprot IDs		Q96DY2	A0A087WUE2 Q9Y6A5
PDB IDs		8J07	5LXN 5LXO 5ODS 5ODT
Enriched GO Terms of Interacting Partners?		Metaphase/anaphase Transition Of Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Nucleus Localization Regulation Of Mitotic Spindle Organization Nuclear Migration Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Spindle Cerebral Cortex Development Centriolar Satellite Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Sister Chromatid Segregation Regulation Of Microtubule Cytoskeleton Organization Mitotic Spindle Organization Spindle Pole Regulation Of Chromosome Segregation Regulation Of Microtubule-based Process Spindle Regulation Of Chromosome Organization Establishment Of Organelle Localization Ciliary Basal Body	Cytoplasm Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Microtubule-based Process Mitotic Centrosome Separation Centrosome Localization Axon Hillock Centrosome Separation
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