PTPMT1 and TAB1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PTPMT1	TAB1
Gene Name		protein tyrosine phosphatase, mitochondrial 1	TGF-beta activated kinase 1/MAP3K7 binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Integral Component Of Mitochondrial Inner Membrane	Nucleoplasm Cytoplasm Cytosol Endosome Membrane Protein Complex
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatidylglycerophosphatase Activity	Catalytic Activity Protein Binding Enzyme Activator Activity Kinase Activator Activity Protein Complex Binding Mitogen-activated Protein Kinase P38 Binding
	Biological Process	Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylglycerol Biosynthetic Process Cardiolipin Biosynthetic Process Peptidyl-tyrosine Dephosphorylation Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Inositol Phosphate Dephosphorylation	Activation Of MAPKKK Activity Activation Of MAPK Activity In Utero Embryonic Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Heart Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Lung Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways		Metabolism of lipids and lipoproteins Synthesis of PG Phospholipid metabolism Glycerophospholipid biosynthesis	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			IgG glycosylation ( 23382691) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		16 interactors: KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP2-4 KRTAP5-9 KRTAP9-2 MAPK6 MDFI MTUS2 NOTCH2NL RGS20 SIAH1 TAB1 TRIM27	61 interactors: ACAP3 ARAP1 ASRGL1 BMPR1A C2orf44 C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A DBN1 EPRS FADD FN1 GIT1 HNRNPR KIFC2 LAP3 LCMT1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SNRNP35 TAB2 TAB3 TRAF2 TRAF6 TRIP6 TRPC4AP TSSC4 URB1 WTAP XIAP XPO7 YWHAG ZMYND11
Entrez ID		114971	10454
HPRD ID		15151	04012
Ensembl ID			ENSG00000100324
Uniprot IDs		Q8WUK0	A8K6K3 Q15750
PDB IDs			2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L53
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation JNK Cascade Negative Regulation Of Interleukin-2 Secretion Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Catalytic Activity Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Regulation Of Phosphorus Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Intracellular Signal Transduction Immune Response Positive Regulation Of MAP Kinase Activity Activation Of MAPK Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Response To Growth Factor Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Signal Transduction By Phosphorylation Apoptotic Process Stress-activated MAPK Cascade
Tagcloud ?			5z attenuated ccr7 chemokine collectively constitutive ikappab ikk importantly invasion jnk jun lymphatic mb mda mediator motif o orthotopic oxozeaenol p38 phospho promotes repressed strongly suppressed tak1 tgf unclear
Tagcloud (Difference) ?			5z attenuated ccr7 chemokine collectively constitutive ikappab ikk importantly invasion jnk jun lymphatic mb mda mediator motif o orthotopic oxozeaenol p38 phospho promotes repressed strongly suppressed tak1 tgf unclear
Tagcloud (Intersection) ?