PTPMT1

Description		protein tyrosine phosphatase mitochondrial 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylglycerophosphatase Activity Hydrolase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylglycerol Biosynthetic Process Phospholipid Biosynthetic Process Cardiolipin Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Synthesis of PG
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Fruit consumption ( 32066663) Glomerular filtration rate ( 29403010) Hypertension ( 27618448) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean arterial pressure ( 27618448) Mood instability ( 31168069) Neuroticism ( 29255261) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Novel Interacting Genes		1 novel interacting genes: CREB3L1
Interacting Genes		32 interacting genes: ADAMTSL4 CYSRT1 GRN KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-4 KRTAP3-1 KRTAP4-12 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE2C MAPK6 MDFI MTUS2 NBPF19 NOTCH2NLA RGS20 SIAH1 SSC4D TAB1 TMEM14B TRIM27
Entrez ID		114971
HPRD ID		15151
Ensembl ID		ENSG00000110536
Uniprot IDs		Q8WUK0
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Epidermis Development Identical Protein Binding Cytosol Structural Molecule Activity Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process
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