OSBPL11 and SNAP25

Number of citations of the paper that reports this interaction (PubMedID 32734583)
70

Data Source:
BioGRID (protein complementation assay)

		OSBPL11	SNAP25
Description		oxysterol binding protein like 11	synaptosome associated protein 25
Image
GO Annotations	Cellular Component	Nucleoplasm Endosome Golgi Apparatus Cytosol Membrane Late Endosome Membrane	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Lipid Binding Sterol Binding	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Lipid Transport Fat Cell Differentiation Triglyceride Homeostasis	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis
Pathways		RHOH GTPase cycle	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs			Botulinum toxin type A Letibotulinumtoxina
Diseases
GWAS			Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)
Interacting Genes		4 interacting genes: AKT1 APP SNAP25 SNCA	45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177
Entrez ID		114885	6616
HPRD ID		09481	02637
Ensembl ID		ENSG00000144909	ENSG00000132639
Uniprot IDs		A0A140VJQ6 Q9BXB4	P60880
PDB IDs		2D9X	1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV
Enriched GO Terms of Interacting Partners?		Cell Cortex Positive Regulation Of Small Molecule Metabolic Process Cellular Response To Metal Ion Regulation Of Generation Of Precursor Metabolites And Energy Growth Cone Positive Regulation Of Synaptic Transmission Synaptic Vesicle Priming Regulation Of Neurotransmitter Uptake Locomotory Behavior Regulation Of Synaptic Plasticity Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Postsynapse Regulation Of Cellular Component Organization Apoptotic Process Positive Regulation Of Phosphate Metabolic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Synapse Organization Response To Growth Factor Programmed Cell Death Cellular Response To Growth Factor Stimulus Regulation Of Protein Localization Cell Death Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Nitric Oxide Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Response To Copper Ion Chemical Synaptic Transmission Amyloid Fibril Formation Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Neurotransmitter Secretion Synaptic Vesicle Exocytosis Neurotransmitter Uptake Response To Metal Ion Response To Nerve Growth Factor Regulation Of Small Molecule Metabolic Process Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Positive Regulation Of Cellular Component Organization Regulation Of Protein Catabolic Process Vesicle-mediated Transport Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Enzyme Binding	SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport
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