SORCS1 and SORT1

Number of citations of the paper that reports this interaction (PMID 12482870)
9

Data Source:
BioGRID (pull down)

		SORCS1	SORT1
Gene Name		sortilin-related VPS10 domain containing receptor 1	sortilin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Integral Component Of Membrane	Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Neuropeptide Receptor Activity	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G-protein Coupled Nerve Growth Factor Binding
	Biological Process	Neuropeptide Signaling Pathway	Ossification Golgi To Endosome Transport Endocytosis G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organismal Development Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Endometriosis ( 23472165)	Cholesterol, total ( 20686565) Chronic kidney disease ( 20383146) Coronary heart disease ( 21378988 21378990) LDL cholesterol ( 18193043 18193044 19060906 19060910 20686565) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Progranulin levels ( 21087763) Response to statin therapy ( 20339536)
Protein-Protein Interactions		2 interactors: FURIN SORT1	8 interactors: BDNF GGA1 GGA2 LRPAP1 NGF NGFR NTS SORCS1
Entrez ID		114815	6272
HPRD ID		12098	03910
Ensembl ID		ENSG00000108018	ENSG00000134243
Uniprot IDs		A8K182 B3KVZ0 B3KWN9 E6Y3F9 E6Y3G0 Q8WY21	Q99523
PDB IDs			3F6K 3G2U 3G2V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Hydrolase Activity Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Lipoprotein Lipase Activity Plasma Membrane To Endosome Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Glucose Import Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Protein Processing Positive Regulation Of Membrane Protein Ectodomain Proteolysis Nerve Growth Factor Signaling Pathway Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Catalytic Activity Golgi To Endosome Transport Enzyme Linked Receptor Protein Signaling Pathway Signal Peptide Processing Negative Regulation Of Lipase Activity Virion Assembly Cellular Response To Nerve Growth Factor Stimulus Endosome To Lysosome Transport Peptide Biosynthetic Process Peptide Hormone Processing Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Lysosomal Transport Myotube Differentiation Collagen Catabolic Process Glucose Transport Negative Regulation Of Cellular Protein Catabolic Process Cellular Response To Organic Substance Hexose Transport Vacuolar Transport Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Neuropeptide Signaling Pathway Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity	Regulation Of Axonogenesis Circadian Rhythm Cellular Response To Nerve Growth Factor Stimulus Response To Electrical Stimulus Rhythmic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Regulation Of Axon Extension Positive Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Response To Anesthetic Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Fluoxetine Response To L-glutamate Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Nerve Development Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Regulation Of Stem Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Size Taste Bud Development Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Neuron Maturation Dendrite Extension Negative Regulation Of Hair Follicle Development Cellular Response To Norepinephrine Stimulus Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Hair Cycle Nerve Growth Factor Processing Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Apoptotic Process Axon Target Recognition Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Response To Norepinephrine Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Response To Ether Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neuron Projection Development Negative Regulation Of Neuron Death Regulation Of Cysteine-type Endopeptidase Activity Cell Projection Morphogenesis
Tagcloud ?		adni associating atrophy classifier correct correction covariates discriminate enlargement enrollment esr1 etiology false happen initiative machines neurodegeneration neuroimaging personalized plans progresses snps sortilin span squares svm tf transferrin vps10	aaa acceptance adequately advances aneurysm avenues bioinformatics chances collaboration confirmatory considerable decade difficulty exploration focusing highlighted identification ldlr lrp1 millions necessity original owing powered progressed robustly unlock variant verified
Tagcloud (Difference) ?		adni associating atrophy classifier correct correction covariates discriminate enlargement enrollment esr1 etiology false happen initiative machines neurodegeneration neuroimaging personalized plans progresses snps sortilin span squares svm tf transferrin vps10	aaa acceptance adequately advances aneurysm avenues bioinformatics chances collaboration confirmatory considerable decade difficulty exploration focusing highlighted identification ldlr lrp1 millions necessity original owing powered progressed robustly unlock variant verified
Tagcloud (Intersection) ?