SORCS1 and SORT1

Number of citations of the paper that reports this interaction (PubMedID 12482870)
0

Data Source:
BioGRID (pull down)

		SORCS1	SORT1
Description		sortilin related VPS10 domain containing receptor 1	sortilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Membrane	Nucleus Lysosome Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Protein Binding Neuropeptide Receptor Activity	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding Retromer Complex Binding
	Biological Process	Post-Golgi Vesicle-mediated Transport Neuropeptide Signaling Pathway	Ossification Protein Targeting To Lysosome Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Cell Differentiation Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation D-glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Golgi To Lysosome Transport Maintenance Of Synapse Structure
Pathways			Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Abnormal white matter microstructure in first episode schizophrenia (multivariate analysis) ( 28924203) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Benign prostatic hyperplasia ( 30988330) Circulating leptin levels in high cardiovascular risk ( 31766143) Endometriosis ( 23472165) Metabolite levels (Pyroglutamine) ( 23934736) Methadone dose in opioid dependence ( 28115739) Systemic juvenile idiopathic arthritis ( 27927641) White matter microstructure in first episode schizophrenia (left posterior cingulate cortex) ( 28924203)	Abdominal aortic aneurysm ( 27899403) Appendicular lean mass ( 33097823) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) Coronary heart disease x type 2 diabetes interaction ( 32541925) HDL cholesterol ( 25961943) LDL cholesterol ( 18193044 25961943 18193043 19060906 19060910 24097068 20686565 21347282) LDL cholesterol levels ( 26690388 28334899) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733) Metabolite levels ( 21909109) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Total cholesterol levels ( 28334899)
Interacting Genes		2 interacting genes: FURIN SORT1	17 interacting genes: ADGRG7 BDNF BRICD5 CNIH3 GGA1 GGA2 LRPAP1 NGF NGFR NTF3 NTRK1 NTRK2 NTRK3 NTS SORCS1 SORL1 TF
Entrez ID		114815	6272
HPRD ID		12098	03910
Ensembl ID		ENSG00000108018	ENSG00000134243
Uniprot IDs		A8K182 B3KVZ0 B3KWN9 E6Y3F9 E6Y3G0 Q8WY21	Q99523
PDB IDs			3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H 8T8R 8T8S
Enriched GO Terms of Interacting Partners?		Nerve Growth Factor Binding Trans-Golgi Network Transport Vesicle Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Nerve Growth Factor Receptor Activity Neurotensin Receptor Activity, Non-G Protein-coupled Endosome Membrane Negative Regulation Of Receptor Catabolic Process Viral Translation Viral Life Cycle Cytokine Precursor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Cerebellar Climbing Fiber To Purkinje Cell Synapse Heparan Sulfate Binding Signal Peptide Processing Plasma Membrane To Endosome Transport Retromer Complex Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Negative Regulation Of Transforming Growth Factor Beta Production Golgi To Lysosome Transport Positive Regulation Of Viral Entry Into Host Cell Golgi To Endosome Transport Nerve Growth Factor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Membrane Protein Ectodomain Proteolysis Endosome Endopeptidase Activator Activity Golgi To Vacuole Transport D-glucose Import Regulation Of Viral Entry Into Host Cell Negative Regulation Of Protein Processing Blastocyst Formation Peptide Biosynthetic Process Negative Regulation Of Protein Maturation Myotube Differentiation Positive Regulation Of Viral Life Cycle Viral Protein Processing Peptide Binding Amyloid Fibril Formation Regulation Of Membrane Protein Ectodomain Proteolysis Neurotrophin Signaling Pathway Maintenance Of Synapse Structure	Neurotrophin Signaling Pathway Neurotrophin Binding Nerve Development Nerve Growth Factor Signaling Pathway Neurotrophin Receptor Activity Nerve Growth Factor Receptor Binding Endosome Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Endosome Membrane Positive Regulation Of Neuron Projection Development Positive Regulation Of Synapse Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Axonogenesis Early Endosome Membrane Enzyme-linked Receptor Protein Signaling Pathway Axon Mechanoreceptor Differentiation Regulation Of Nervous System Development Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cell Junction Assembly Dendrite Regulation Of Neuron Apoptotic Process Rhythmic Process Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Nervous System Development Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Nerve Growth Factor Binding Cellular Response To Nerve Growth Factor Stimulus Regulation Of Axonogenesis Signal Transduction Nervous System Development Early Endosome Response To Nerve Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synapse Assembly Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Regulation Of Signal Transduction Establishment Of Protein Localization To Plasma Membrane System Development Signaling Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development
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