SORCS1

Description		sortilin related VPS10 domain containing receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Membrane
	Molecular Function	Protein Binding Neuropeptide Receptor Activity
	Biological Process	Post-Golgi Vesicle-mediated Transport Neuropeptide Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Abnormal white matter microstructure in first episode schizophrenia (multivariate analysis) ( 28924203) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Benign prostatic hyperplasia ( 30988330) Circulating leptin levels in high cardiovascular risk ( 31766143) Endometriosis ( 23472165) Metabolite levels (Pyroglutamine) ( 23934736) Methadone dose in opioid dependence ( 28115739) Systemic juvenile idiopathic arthritis ( 27927641) White matter microstructure in first episode schizophrenia (left posterior cingulate cortex) ( 28924203)
Interacting Genes		2 interacting genes: FURIN SORT1
Entrez ID		114815
HPRD ID		12098
Ensembl ID		ENSG00000108018
Uniprot IDs		A8K182 B3KVZ0 B3KWN9 E6Y3F9 E6Y3G0 Q8WY21
PDB IDs
Enriched GO Terms of Interacting Partners?		Nerve Growth Factor Binding Trans-Golgi Network Transport Vesicle Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Nerve Growth Factor Receptor Activity Neurotensin Receptor Activity, Non-G Protein-coupled Endosome Membrane Negative Regulation Of Receptor Catabolic Process Viral Translation Viral Life Cycle Cytokine Precursor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Cerebellar Climbing Fiber To Purkinje Cell Synapse Heparan Sulfate Binding Signal Peptide Processing Plasma Membrane To Endosome Transport Retromer Complex Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Negative Regulation Of Transforming Growth Factor Beta Production Golgi To Lysosome Transport Positive Regulation Of Viral Entry Into Host Cell Golgi To Endosome Transport Nerve Growth Factor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Membrane Protein Ectodomain Proteolysis Endosome Endopeptidase Activator Activity Golgi To Vacuole Transport D-glucose Import Regulation Of Viral Entry Into Host Cell Negative Regulation Of Protein Processing Blastocyst Formation Peptide Biosynthetic Process Negative Regulation Of Protein Maturation Myotube Differentiation Positive Regulation Of Viral Life Cycle Viral Protein Processing Peptide Binding Amyloid Fibril Formation Regulation Of Membrane Protein Ectodomain Proteolysis Neurotrophin Signaling Pathway Maintenance Of Synapse Structure
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