ZBED10P and MAPK7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZBED10P	MAPK7
Description		zinc finger BED-type containing 10, pseudogene	mitogen-activated protein kinase 7
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Enzyme Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process		MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Calcineurin-NFAT Signaling Cascade Cellular Response To Stress Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signaling Cassette Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs			Acetylsalicylic acid Minocycline Colforsin Fostamatinib
Diseases
GWAS			Alzheimer's disease ( 30636644)
Interacting Genes		1 interacting genes: MAPK7	31 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED10P ZKSCAN1
Entrez ID		113763	5598
HPRD ID		12917	03952
Ensembl ID			ENSG00000166484
Uniprot IDs			Q13164
PDB IDs			2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN 7PUS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heterotypic Cell-cell Adhesion Cellular Response To Fluid Shear Stress Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Calcium-mediated Signaling Mitogen-activated Protein Kinase Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway MAP Kinase Activity Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Laminar Fluid Shear Stress Response To Laminar Fluid Shear Stress Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Endothelial Cell Apoptotic Process Enzyme Inhibitor Activity Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Hydrogen Peroxide Response To Transforming Growth Factor Beta Response To Hydrogen Peroxide Regulation Of Calcium-mediated Signaling Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Reactive Oxygen Species Negative Regulation Of Intrinsic Apoptotic Signaling Pathway PML Body Regulation Of Extrinsic Apoptotic Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Reactive Oxygen Species Calcium-mediated Signaling Negative Regulation Of Inflammatory Response Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell-cell Adhesion Cellular Response To Oxidative Stress Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway MAPK Cascade Cellular Response To Chemical Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Defense Response Negative Regulation Of Cell Adhesion Response To Growth Factor Regulation Of Angiogenesis	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Sequence-specific DNA Binding Regulation Of Cell Migration RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription MAPK Cascade Regulation Of Cell Motility Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of MiRNA Metabolic Process Regulation Of Locomotion DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II ERK5 Cascade Positive Regulation Of Multicellular Organismal Process Positive Regulation Of MiRNA Transcription Signal Transduction Histone Deacetylase Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of MiRNA Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process
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