SYNPO and NCK2

Number of citations of the paper that reports this interaction (PMID 24287595)
1

Data Source:
BioGRID (pull down)

		SYNPO	NCK2
Gene Name		synaptopodin	NCK adaptor protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Tight Junction Postsynaptic Density Actin Cytoskeleton Dendritic Spine Perikaryon Postsynaptic Membrane	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane
	Molecular Function	Actin Binding Protein Binding	SH3/SH2 Adaptor Activity Protein Binding Cytoskeletal Adaptor Activity Receptor Signaling Complex Scaffold Activity
	Biological Process	Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly	Regulation Of Translation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways			Signaling by PDGF Ephrin signaling Axon guidance Activation of Rac Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling Nephrin interactions Signaling by Robo receptor VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Addiction ( 23533358)
Protein-Protein Interactions		6 interactors: MAGI1 NCK1 NCK2 NONO YWHAG YWHAZ	80 interactors: ABI1 ABI2 ABI3 ARHGAP32 ATN1 AXIN1 AXL BCL11A CBLB CCDC33 CD3E CHN1 CPSF6 CPSF7 DDR1 DNM1 DOCK1 DOK1 DRAP1 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EGFR EIF3H ERBB2 ERBB3 FAM53C FASLG FCRL2 FGFR1 FXR2 HNRNPK HOMEZ HOXC4 ILK IRS1 KHDRBS1 KIAA1217 LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MEOX2 NCKIPSD NPHS1 NR5A1 NTRK2 PAK1 PDGFRB PKN2 PRR20A PSMD10 PTK2 RASSF7 RBM26 REL SF3B4 SORBS2 SOS1 SPRY2 SRPK1 SRPK2 SYNPO TCF4 TNR TRIM27 TRIM41 TRIP6 VARS2 VPS37B WAS WASL WBP11 WIPF2 ZBTB7B
Entrez ID		11346	8440
HPRD ID		12179	05378
Ensembl ID		ENSG00000171992	ENSG00000071051
Uniprot IDs		Q8N3V7	E7ERP6 O43639
PDB IDs			1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Regulation Of Peptidyl-serine Phosphorylation Regulation Of Signal Transduction Signal Complex Assembly Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Organelle Organization Lamellipodium Assembly Regulation Of Protein Phosphorylation Lamellipodium Organization Positive Regulation Of Mitochondrion Organization Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Cell Death Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Protein Polymerization Cell Activation Cellular Response To Stimulus Positive Regulation Of Translation In Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Cellular Component Assembly Regulation Of T Cell Proliferation Regulation Of Protein Kinase Activity Positive Regulation Of Transport	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Signaling Movement Of Cell Or Subcellular Component Cell Communication Immune Response Locomotion Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Peptidyl-tyrosine Phosphorylation Axon Guidance Intracellular Signal Transduction Cell Migration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Anatomical Structure Development Positive Regulation Of Protein Metabolic Process Cell Development Gene Expression Regulation Of Cellular Process Immune System Process Cell Motility System Development Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Multicellular Organismal Development Chemotaxis Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Axon Development Developmental Process Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development
Tagcloud ?		appearances barely cxxc5 deg degs egfl7 exclusions exon fhl1 foxm1 gains hub inclusions ingenuity ipa maz multilateral ndrg2 pah phh plk1 rcan1 reads seq signatures suddenly tmpo transcriptomic ttll1	accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Difference) ?		appearances barely cxxc5 deg degs egfl7 exclusions exon fhl1 foxm1 gains hub inclusions ingenuity ipa maz multilateral ndrg2 pah phh plk1 rcan1 reads seq signatures suddenly tmpo transcriptomic ttll1	accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Intersection) ?