MSRB3 and MED12L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MSRB3	MED12L
Description		methionine sulfoxide reductase B3	mediator complex subunit 12L
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol	Nucleus Mediator Complex
	Molecular Function	Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity Metal Ion Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding
	Biological Process	Response To Oxidative Stress Protein Repair	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Protein repair
Drugs
Diseases
GWAS		A body shape index ( 34021172) Antisaccade task score ( 31596458) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical volume ( 32963231) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)	Chronotype ( 30696823) Eosinophil count ( 32888494) Epstein-Barr virus EBNA-1 antibody levels ( 33204752) Heschl's gyrus morphology ( 25130324) Lymphocyte count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Trunk fat mass ( 28552196) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: ASB13 BANP EEF1AKMT3 EFEMP1 EIF6 FAM168B FHL3 GOLGA2 KRT31 KRT34 KRT40 LCN2 LNX2 MAPK8IP2 MED12L METTL15 METTL21A MGLL PICK1 PLEKHG4 POU6F2 PRDM4 REL SKIC8 TCF4 TRIM23 TRIM55 TRIM63 TRIP6 UFSP1 ZMYND12	7 interacting genes: AR CKS1B LAMTOR5 MAPK9 MSRB3 TLE5 TTC23
Entrez ID		253827	116931
HPRD ID		14785	10278
Ensembl ID		ENSG00000174099	ENSG00000144893
Uniprot IDs		Q8IXL7	A0A8I5KX78 B3KXY0 Q86YW9
PDB IDs		6QA0
Enriched GO Terms of Interacting Partners?		Intermediate Filament Structural Constituent Of Skin Epidermis Structural Molecule Activity Intermediate Filament Organization Methyltransferase Activity Protein Modification Process Protein Binding Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Methylation
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