MSRB3 and SKIC8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MSRB3	SKIC8
Description		methionine sulfoxide reductase B3	SKI8 subunit of superkiller complex
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol	Euchromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Ski Complex
	Molecular Function	Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity Metal Ion Binding	Protein Binding
	Biological Process	Response To Oxidative Stress Protein Repair	Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome
Pathways		Protein repair	Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Antisaccade task score ( 31596458) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical volume ( 32963231) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		31 interacting genes: ASB13 BANP EEF1AKMT3 EFEMP1 EIF6 FAM168B FHL3 GOLGA2 KRT31 KRT34 KRT40 LCN2 LNX2 MAPK8IP2 MED12L METTL15 METTL21A MGLL PICK1 PLEKHG4 POU6F2 PRDM4 REL SKIC8 TCF4 TRIM23 TRIM55 TRIM63 TRIP6 UFSP1 ZMYND12	11 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 MSRB3 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ
Entrez ID		253827	80349
HPRD ID		14785	15236
Ensembl ID		ENSG00000174099	ENSG00000140395
Uniprot IDs		Q8IXL7	H0YL19 Q9GZS3
PDB IDs		6QA0	3OW8 6GMH 6TED 7OOP 7OPC 7OPD 7QDR 7QDS 7QDY 7QDZ 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9G8O 9G8Q 9G8R
Enriched GO Terms of Interacting Partners?		Intermediate Filament Structural Constituent Of Skin Epidermis Structural Molecule Activity Intermediate Filament Organization Methyltransferase Activity Protein Modification Process Protein Binding Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Methylation	Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Activin Receptor Signaling Pathway I-SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Pharyngeal System Development Regulation Of Metabolic Process Regulation Of Gene Expression Transforming Growth Factor Beta Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Mitotic Cell Cycle Phase Transition Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA-templated Transcription Response To Stress Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Keratinocyte Differentiation Ventricular Septum Morphogenesis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding Negative Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Endocardial Cushion Cell Fate Commitment Negative Regulation Of MRNA 3'-end Processing Hepatocyte Homeostasis Type 8 Metabotropic Glutamate Receptor Binding Engulfment Of Target By Autophagosome Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Cycle Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Epidermal Cell Differentiation Gland Development Cellular Response To Growth Factor Stimulus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
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