PDAP1 and SF1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PDAP1	SF1
Description		PDGFA associated protein 1	splicing factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Spliceosomal Complex Ribosome U2AF Complex
	Molecular Function	RNA Binding Protein Binding	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Primary Metabolic Process
Pathways		Neutrophil degranulation	mRNA Splicing - Major Pathway
Drugs			Artenimol
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620) Mean spheric corpuscular volume ( 32888494) Serum metabolite levels ( 23093944)	Mean reticulocyte volume ( 32888494) Urate levels ( 21768215)
Interacting Genes		9 interacting genes: APP CEBPA CSNK2A1 CWC22 FZD7 PDGFA PDGFB PDGFRB SF1	90 interacting genes: ALG13 APBB1 APOBEC3C ATXN1 BAG4 BCAS2 BCL2 BUD31 CDC42 CEBPA CEP55 CPSF7 CTBP1 CTTN DCN DDX17 DMRTB1 DUX4L9 EWSR1 EXOSC1 EXOSC8 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IDH3A IL7R ILF3 ITCH KHDRBS2 KPNA1 KRT31 KRTAP26-1 LINC00632 MIR106B MIR155 MIR19B2 MIR34A MIRLET7G MKRN3 NCK2 NEIL3 NFKB1 OGT OSTF1 PDAP1 PLSCR1 PRKG1 PRPF39 PRPF40A PRRC2B PSMA3 PUF60 PUS7 RBFOX2 RBM10 RBM17 RBM4 RBM7 RBMX RBPMS RPA2 RSPH1 SEC23A SF3B1 SF3B4 SFPQ SNRPA TAF15 TCERG1 TFIP11 TNPO2 TRIM23 TRIM69 TTN TXNL4B U2AF2 UBL5 USO1 WBP4 WDR77 WDR83 WWP2 YTHDF1 YTHDF3 ZNF461
Entrez ID		11333	7536
HPRD ID		06149	03306
Ensembl ID		ENSG00000106244	ENSG00000168066
Uniprot IDs		Q13442	A0A7P0T9U7 A0A9L9PXE4 B4DX42 H7C561 Q15637
PDB IDs			1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX 7VH9 7VPX 8PXX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Platelet-derived Growth Factor Binding Platelet-derived Growth Factor Receptor Binding Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Platelet Alpha Granule Lumen Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Autophosphorylation Smooth Muscle Adaptation Positive Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Glomerular Mesangial Cell Proliferation Chemotaxis Golgi Lumen Protein Heterodimerization Activity Regulation Of Protein Autophosphorylation Locomotion Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Receptor Ligand Activity Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Platelet Activation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Chemotaxis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Platelet-derived Growth Factor Stimulus Embryonic Organ Development Response To Platelet-derived Growth Factor	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process RNA Binding RNA Metabolic Process Nucleic Acid Binding Regulation Of RNA Splicing Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression MRNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Speck Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Identical Protein Binding Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA 3'-UTR Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Splicing
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