PRR4 and GET3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PRR4	GET3
Name		proline rich 4	guided entry of tail-anchored proteins factor 3, ATPase
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Membrane Insertase Activity Metal Ion Binding
	Biological Process	Visual Perception	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		None	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		None	ATP
GWAS		Caffeine consumption from tea ( 33287642 )	No GWAS studies recorded
Interacting Genes		6 interacting genes: GET3 LAT MIEF1 SGTB UBQLN1 UBQLN2	38 interacting genes: AGR2 APLN ASPH CACNA1A CREB3L4 EMSY FAM209A FKBP7 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		11272	439
HPRD ID		09248	03555
Ensembl ID		ENSG00000111215	ENSG00000198356
Uniprot IDs		Q16378	O43681
PDB IDs		Not available	6SO5 8CQZ 8CR1 8CR2
GO Terms Enriched among Interactors		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Molecular Condensate Scaffold Activity Localization Within Membrane TCR Signalosome Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Organization Autophagosome Assembly ERAD Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity TRC Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process GET Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Clathrin-dependent Endocytosis Identical Protein Binding Positive Regulation Of Mitochondrial Fusion Vacuole Organization Positive Regulation Of Protein Metabolic Process Regulation Of Macroautophagy Establishment Of Protein Localization To Membrane Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Membrane Raft Distribution Membrane Raft Localization Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Autophagy Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Mitochondrial Fusion Aggrephagy Mitochondrial Fission Membrane Insertase Activity Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Receptor Internalization Positive Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Clathrin-dependent Endocytosis Mitochondrial Fusion Regulation Of Proteolysis Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Mitochondrial Fission	Extracellular Region Endoplasmic Reticulum Lumen Intracellular Protein Transmembrane Transport Body Fluid Secretion Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Extracellular Space Regulation Of Body Fluid Levels Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Mucus Secretion Potassium Ion Export Across Plasma Membrane Protein Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Regulation Of Heart Contraction Amyloid-beta Binding Glutathione Peroxidase Activity Protein Disulfide Isomerase Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein Binding Regulation Of System Process Protein-disulfide Reductase Activity