CLEC10A and MALL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC10A	MALL
Description		C-type lectin domain containing 10A	mal, T cell differentiation protein like
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Early Endosome Membrane	Golgi Membrane Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding	Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Adaptive Immune Response Immune System Process Endocytosis Immune Response Innate Immune Response	Myelination Cholesterol Homeostasis
Pathways		Dectin-2 family
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Liver enzyme levels (alkaline phosphatase) ( 33972514) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		26 interacting genes: ACSF2 ADIPOQ APOD BET1 C3orf52 CFTR CLN6 FMO3 FXYD6 GIMAP1 MALL NAPB PEX16 PRAF2 SEC22A SLC38A7 SMCO4 SNCA TMEM218 TNF TRARG1 TSPO UNC50 VSTM1 ZDHHC15 ZFPL1	69 interacting genes: AMIGO1 AQP6 ARL13B ATP5PF BEST2 BNIP3 BNIP3L BRI3 BSCL2 CAV1 CAV2 CD79A CLDN7 CLDN9 CLEC10A CLEC12B CLEC14A CPLX4 CREB3 CREB3L1 CRHR2 CTLA4 DAGLA DCBLD2 ELOVL2 ELOVL4 EMP1 ERGIC3 EVI2A FCGR1A FFAR2 FNDC9 GGT7 GJA8 GPA33 IL7R KASH5 KLRC1 LDLRAD1 LEPROTL1 LMNA MANBAL MCEMP1 MS4A12 MSR1 MUC1 OPRM1 PGRMC2 PLA2G2E RETREG3 RNF185 SIGLEC6 SIT1 SLC10A1 SLC10A6 SLC18A1 SLC35H1 STMN4 STX1A SYNE4 SYT2 TMEM139 TMEM182 TMEM248 TMEM31 TMEM80 TMX2 UBE2I ZP3
Entrez ID		10462	7851
HPRD ID		12076	15997
Ensembl ID		ENSG00000132514	ENSG00000144063
Uniprot IDs		J3KR22 Q8IUN9	Q13021
PDB IDs		6PUV 6PY1 6W12 6XIY
Enriched GO Terms of Interacting Partners?		Membrane Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Protein Localization To Membrane Regulation Of Lipid Metabolic Process Negative Regulation Of Secretion Cellular Response To Epinephrine Stimulus Intracellular Protein Localization Positive Regulation Of Monoatomic Ion Transport Response To Epinephrine Regulation Of Chemokine Production Negative Regulation Of Transport Axon Regeneration Establishment Of Protein Localization Regulation Of Oxidative Phosphorylation Regulation Of Smooth Muscle Cell Proliferation Lipid Metabolic Process Glucose Metabolic Process Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Negative Regulation Of Lipoprotein Lipid Oxidation Neuron Projection Regeneration Regeneration Small Molecule Metabolic Process Regulation Of Hormone Secretion Response To Xenobiotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Secretion By Cell Positive Regulation Of Transport Negative Regulation Of Secretion By Cell Positive Regulation Of Glial Cell Proliferation Regulation Of Small Molecule Metabolic Process Negative Regulation Of Corticosterone Secretion Negative Regulation Of Lipid Transport Chemical Homeostasis Response To Alcohol Positive Regulation Of Monoatomic Ion Transmembrane Transport Endoplasmic Reticulum Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Albendazole Monooxygenase Activity Response To Desipramine Regulation Of Aerobic Respiration Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	Membrane Protein Binding Plasma Membrane Caveolar Macromolecular Signaling Complex Nuclear Envelope Adaptive Immune Response Natural Killer Cell Inhibitory Signaling Pathway Endoplasmic Reticulum-autophagosome Adaptor Activity Carbohydrate Binding External Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Membrane Organization Immune Response-regulating Signaling Pathway Lipid Storage Positive Regulation Of Hypersensitivity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Substrate Localization To Autophagosome Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Fatty Acid Elongation, Saturated Fatty Acid Mitochondrial Outer Membrane Permeabilization Caveola Assembly Organic Hydroxy Compound Transport Regulation Of Response To Endoplasmic Reticulum Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Mitochondrial Protein Catabolic Process Plasma Membrane Raft Assembly Negative Regulation Of T Cell Mediated Cytotoxicity Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Acute Inflammatory Response Immune Response-inhibiting Signal Transduction
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