MRPL3 and CD80

		MRPL3	CD80
Description		mitochondrial ribosomal protein L3	CD80 molecule
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion
	Molecular Function	RNA Binding Structural Constituent Of Ribosome	Virus Receptor Activity Protein Binding Coreceptor Activity Receptor Ligand Activity
	Biological Process	Translation Mitochondrial Translation	Immune System Process Regulation Of Immune System Process Negative Regulation Of T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction T Cell Costimulation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-2 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Lipopolysaccharide
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Abatacept Galiximab Belatacept
Diseases
GWAS		Body mass index ( 26426971)	Asthma ( 32296059) Autoimmune thyroid disease ( 32581359) Carotid plaque burden ( 28282560) Celiac disease ( 20190752) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446) Primary biliary cholangitis ( 21399635 28425483 28062665 26394269 23000144) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 25862617 23273568) Systemic sclerosis ( 31672989) Vitiligo ( 27723757 22561518)
Interacting Genes		2 interacting genes: APP ERCC6	5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR
Entrez ID		11222	941
HPRD ID		06175	00202
Ensembl ID		ENSG00000114686	ENSG00000121594
Uniprot IDs		P09001	A0N0P2 P33681
PDB IDs		3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5H 7A5I 7A5J 7A5K 7L08 7L20 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF4 7OF5 7OF6 7OF7 7OG4 7OI6 7OI7 7OI8 7OI9 7OIA 7OIB 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 7QI4 7QI5 7QI6 8ANY 8K2A 8K2B 8OIR 8OIT 8PK0 8QSJ 8QU1 8QU5 8RRI 8XT0 8XT1 8XT2 8XT3	1DR9 1I8L 7TPS 8FXW 8FXZ 8HXA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphate Metabolic Process Neuron Projection Organization Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Membrane Raft Amyloid-beta Complex PTB Domain Binding Regulation Of Synapse Assembly Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway System Development Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Cell Recognition Early Endosome Membrane Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Neuron Projection Development Receptor Ligand Activity Lipoprotein Particle Cell Projection Organization Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Cell Activation Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Low-density Lipoprotein Particle Mediated Signaling Protein Complex Involved In Cell Adhesion Positive Regulation Of Protein Phosphorylation Optic Nerve Morphogenesis Negative Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Hindbrain Tangential Cell Migration	T Cell Costimulation Regulation Of T Cell Proliferation Protein Complex Involved In Cell Adhesion Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Leukocyte Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of T Cell Proliferation External Side Of Plasma Membrane Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Alpha-beta T Cell Activation Regulation Of T Cell Activation Negative Regulation Of T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-4 Production Regulation Of Cell-cell Adhesion Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Regulation Of T Cell Differentiation Regulation Of Interleukin-4 Production Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cell Activation Positive Regulation Of Interleukin-10 Production Regulation Of Cell Activation Positive Regulation Of Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Immunoglobulin Production Adaptive Immune Response Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Interleukin-2 Production Regulation Of Interleukin-10 Production Thyrotropin-releasing Hormone Activity Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process
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