CHML and SERPINC1

Data Source: HiPPIP (Novel)

		CHML	SERPINC1
Name		CHM like Rab escort protein	serpin family C member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	GDP-dissociation Inhibitor Activity GTPase Activator Activity Small GTPase Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Intracellular Protein Transport Small GTPase-mediated Signal Transduction Vesicle-mediated Transport Protein Geranylgeranylation	Blood Coagulation Hemostasis Regulation Of Blood Coagulation
Pathways		RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		None	Ardeparin Fondaparinux Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Danaparoid Dalteparin Tinzaparin Nadroparin Copper Protamine sulfate Bemiparin Antithrombin III human
Diseases		None	Inherited thrombophilia
GWAS		Daytime sleep phenotypes ( 27126917 )	Experiencing mood swings ( 29500382 ) Heel bone mineral density ( 30598549 )
Novel Interactors		1 novel interactors: SERPINC1	7 novel interactors: ATP1B1 CHML CREG1 FMO3 MRPS14 PIGC QSOX1
Interacting Genes		5 interacting genes: RAB1A RAB3A RAB5A RAB6A RABGGTB	7 interacting genes: F2 HSP90AA1 KLK1 KLK2 KLK6 PLG SDC2
Entrez ID		1122	462
HPRD ID		00341	00122
Ensembl ID		ENSG00000203668	ENSG00000117601
Uniprot IDs		P26374	P01008
PDB IDs		Not available	1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
GO Terms Enriched among Interactors		GTPase Activity GTP Binding Vesicle-mediated Transport Myosin V Binding Synaptic Vesicle Recycling Establishment Of Localization In Cell Endomembrane System Establishment Of Organelle Localization Golgi Vesicle Transport Terminal Bouton Regulation Of Synaptic Vesicle Exocytosis Regulation Of Neuronal Synaptic Plasticity Peptide Hormone Secretion Organelle Localization Protein Transport Intracellular Transport Organelle Transport Along Microtubule Peptide Secretion G Protein Activity Regulation Of Presynaptic Dense Core Granule Exocytosis Regulation Of Neurotransmitter Secretion Positive Regulation Of Exocytosis Evoked Neurotransmitter Secretion Peptidyl-cysteine Methylation Establishment Of Protein Localization Hormone Secretion Peptide Transport Secretory Granule Membrane Hormone Transport Melanosome Intracellular Protein Transport Establishment Of Vesicle Localization Sensory Perception Of Touch Vesicle Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Regulated Secretory Pathway Synaptic Vesicle Synaptic Vesicle Membrane Amide Transport Hydrolase Activity Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Regulation Of Dense Core Granule Exocytosis Protein Localization To Early Endosome Endosome To Plasma Membrane Transport Vesicle Nucleotide Binding Intracellular Protein Localization Signal Release Clathrin-sculpted Glutamate Transport Vesicle Membrane Cytoplasmic Side Of Early Endosome Membrane	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Protein Processing Peptidase Activity Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Space Secretory Granule Regulation Of Fibrinolysis Fibrinolysis Protein Maturation MHC Class II Protein Complex Binding Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Biological Quality Biological Process Involved In Interaction With Symbiont Zymogen Activation Protein Metabolic Process Negative Regulation Of Coagulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Extracellular Region Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Albendazole Monooxygenase Activity CTP Binding DATP Binding Regulation Of Systemic Arterial Blood Pressure Tissue Regeneration Hydrolase Activity Cellular Homeostasis Protein Transport Into Plasma Membrane Raft Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Lumen Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Platelet Alpha Granule Lumen Proteolysis Regulation Of Cardiac Muscle Contraction Striated Muscle Contraction Endopeptidase Activity Rho GDP-dissociation Inhibitor Binding Lysosomal Lumen Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Flavin-dependent Sulfhydryl Oxidase Activity