POLI and REV1

Number of citations of the paper that reports this interaction (PMID 15189446)
57

Data Source:
HPRD (two hybrid)

		POLI	REV1
Gene Name		polymerase (DNA directed) iota	REV1, polymerase (DNA directed)
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Nucleoplasm
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding	Magnesium Ion Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Deoxycytidyl Transferase Activity
	Biological Process	DNA Replication DNA Repair DNA Biosynthetic Process	DNA Replication DNA Repair Response To UV Error-prone Translesion Synthesis
Pathways			DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template Translesion synthesis by HREV1
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		16 interactors: APP CALCOCO2 DAZAP2 DVL2 PCNA POLH REV1 RNF11 TMEM239 TRAF6 TRIM23 TRIM39 UBA52 UBB UBC ZBTB44	8 interactors: FHL2 MAD2L2 POLDIP2 POLH POLI POLK POLL REV3L
Entrez ID		11201	51455
HPRD ID		16094	16202
Ensembl ID		ENSG00000101751	ENSG00000135945
Uniprot IDs		J3KQ09 Q9UNA4	Q9UBZ9
PDB IDs		1T3N 1ZET 2ALZ 2DPI 2DPJ 2FLL 2FLN 2FLP 2KHU 2KHW 2KTF 2L0F 2L0G 3EPG 3EPI 3G6V 3G6X 3G6Y 3GV5 3GV7 3GV8 3H40 3H4B 3H4D 3NGD 3OSN 3Q8P 3Q8Q 3Q8R 3Q8S 4EBC 4EBD 4EBE 4EYH 4EYI 4FS1 4FS2	2EBW 2LSI 2LSK 2LSY 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Viral Protein Processing I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Intracellular Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of ERBB Signaling Pathway JNK Cascade Postreplication Repair Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Notch Receptor Processing Virion Assembly Negative Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Serine/threonine Kinase Activity Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of MAP Kinase Activity Glycogen Biosynthetic Process Intracellular Transport Of Virus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade DNA Repair Positive Regulation Of Catalytic Activity Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Notch Signaling Pathway Activation Of MAPK Activity Activation Of Innate Immune Response	DNA Biosynthetic Process DNA Repair DNA Replication Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Postreplication Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Nitrogen Compound Metabolic Process Nucleotide-excision Repair DNA-dependent DNA Replication Cellular Response To Stimulus Atrial Cardiac Muscle Cell Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Error-prone Translesion Synthesis Negative Regulation Of APC-Cdc20 Complex Activity Negative Regulation Of Transcription By Competitive Promoter Binding Response To Stimulus Translesion Synthesis Response To UV-C Pyrimidine Dimer Repair DNA Damage Response, Signal Transduction Resulting In Transcription Somatic Hypermutation Of Immunoglobulin Genes Heart Trabecula Formation DNA Synthesis Involved In DNA Repair Negative Regulation Of Transcription Regulatory Region DNA Binding Somatic Diversification Of Immune Receptors Via Somatic Mutation Nucleotide-excision Repair, DNA Gap Filling Ventricular Cardiac Muscle Cell Development Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription Regulatory Region DNA Binding Mitochondrion Morphogenesis Heart Trabecula Morphogenesis Ventricular Cardiac Muscle Cell Differentiation
Tagcloud ?		acad accordance asp125 asp148 asp150 catalysed dideoxynucleotide discriminate enzymatically exonucleolytic exploitable gapped heteropolymer homo invariant lacked natl neutralisation nicked nuclease overproduced polymerisation predictions proc proofreading richardson tabor terminating triphosphates	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief sensing short specialized starvation sumo2 suppressor therapies toxic turn
Tagcloud (Difference) ?		acad accordance asp125 asp148 asp150 catalysed dideoxynucleotide discriminate enzymatically exonucleolytic exploitable gapped heteropolymer homo invariant lacked natl neutralisation nicked nuclease overproduced polymerisation predictions proc proofreading richardson tabor terminating triphosphates	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief sensing short specialized starvation sumo2 suppressor therapies toxic turn
Tagcloud (Intersection) ?