AUH

Description		AU RNA binding methylglutaconyl-CoA hydratase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Catalytic Activity Enoyl-CoA Hydratase Activity Methylglutaconyl-CoA Hydratase Activity Lyase Activity Itaconyl-CoA Hydratase Activity
	Biological Process	L-leucine Catabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process
Pathways		Branched-chain amino acid catabolism 3-methylglutaconic aciduria
Drugs
Diseases		3-Methylglutaconic aciduria (MGCA)
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Inflammatory bowel disease ( 28067908) Response to Homoharringtonine (cytotoxicity) ( 25628645) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total bilirubin levels ( 29403010) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		1 interacting genes: FAM107A
Entrez ID		549
HPRD ID		08987
Ensembl ID		ENSG00000148090
Uniprot IDs		B4DYI6 Q13825
PDB IDs		1HZD 2ZQQ 2ZQR
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Synaptic Potentiation Regulation Of Cell-substrate Junction Organization Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell-matrix Adhesion Actin Polymerization Or Depolymerization Actin Filament Polymerization Regulation Of Focal Adhesion Assembly Actin Filament Bundle Organization Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Polymerization Negative Regulation Of Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cell-substrate Adhesion Cellular Response To Steroid Hormone Stimulus Stress Fiber Ruffle Membrane Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Regulation Of Cell-matrix Adhesion Response To Glucocorticoid Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Response To Corticosteroid Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Synaptic Plasticity Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Response To Steroid Hormone Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Cycle Phase Transition Regulation Of Microtubule-based Process Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Post-translational Protein Modification Cellular Response To Nutrient Levels Negative Regulation Of Cell Cycle Process Actin Cytoskeleton Negative Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Cognition Neuron Projection Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Hormone Stimulus Negative Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Actin Filament-based Process
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