UBE3D

Description		ubiquitin protein ligase E3D
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Ribonuclease Inhibitor Activity Transferase Activity Cyclin Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Crohn's disease ( 26891255) Entorhinal cortical volume ( 31530798) Heel bone mineral density ( 28869591 30598549) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189)
Interacting Genes		5 interacting genes: CCNB1 MAGEA11 PCNA TRIM28 UBE2C
Entrez ID		90025
HPRD ID		12861
Ensembl ID		ENSG00000118420
Uniprot IDs		D6RD24 Q4G0J6 Q4G0X5 Q7Z6J8
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-like Protein Ligase Binding Cellular Response To Iron(III) Ion Positive Regulation Of Mitotic Cell Cycle Phase Transition Response To DDT Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Positive Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Sister Chromatid Separation Regeneration Regulation Of Chromosome Separation PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Krueppel-associated Box Domain Binding Nucleoplasm Positive Regulation Of DNA Repair Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Ubiquitin-like Protein Ligase Activity Response To Iron(III) Ion Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Embryonic Placenta Morphogenesis Positive Regulation Of Exit From Mitosis Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of MRNA 3'-end Processing Response To Insecticide Regulation Of Primary Metabolic Process Regulation Of Chromosome Organization Chordate Embryonic Development In Utero Embryonic Development Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Repair MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Positive Regulation Of Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization
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