RNF167 and SESN2

Number of citations of the paper that reports this interaction (PubMedID 35114100)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, pull down)

		RNF167	SESN2
Description		ring finger protein 167	sestrin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Organelle Membrane Endolysosome Membrane	Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Nucleotide-activated Protein Kinase Complex TORC2 Complex Atg1/ULK1 Kinase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Peroxidase Activity GDP-dissociation Inhibitor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Sulfiredoxin Activity PH Domain Binding Protein-containing Complex Binding L-leucine Binding Protein Sequestering Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Nutrient Levels Lysosome Localization Cellular Response To Amino Acid Starvation Protein K29-linked Ubiquitination Negative Regulation Of Cell Cycle Organelle Localization Regulation Of Synaptic Transmission, Glutamatergic Protein K63-linked Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Regulation Of Protein Phosphorylation Regulation Of Gluconeogenesis Fatty Acid Beta-oxidation Mitochondrion Organization Response To Glucose Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Mitochondrial DNA Metabolic Process Response To Insulin Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Glucose Homeostasis D-glucose Import Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Triglyceride Homeostasis Protein K63-linked Ubiquitination Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Reactive Oxygen Species Metabolic Process Protein K6-linked Ubiquitination Cellular Oxidant Detoxification Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Protein Localization To Nucleus Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Lipophagy Cellular Response To Leucine Starvation
Pathways			TP53 Regulates Metabolic Genes Amino acids regulate mTORC1 KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Keratoconus ( 33649486) Platelet count ( 32888494) Plateletcrit ( 32888494)	Aspartate aminotransferase levels ( 33547301) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		33 interacting genes: ACTA1 AFG3L2 ATP2A1 CAPN3 CDC34 EGFR GRIA2 MDK MYH7 PDCD1 PTN RAB7A SESN2 SLC67A1 SUMO1 TAFA2 TAFA5 TOLLIP TTN UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2G2 UBE2K UBE2N UBE2T UBE2W	6 interacting genes: CRYAA MDM2 PRDX1 RNF167 RNF186 STAMBPL1
Entrez ID		26001	83667
HPRD ID		15261	06378
Ensembl ID		ENSG00000108523	ENSG00000130766
Uniprot IDs		Q9H6Y7	P58004
PDB IDs			5CUF 5DJ4 5T0N 6N0M
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation ATP Binding Protein Ubiquitination Protein K11-linked Ubiquitination Nucleotide Binding Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Catabolic Process Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein K6-linked Ubiquitination Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling DNA Metabolic Process Protein Autoubiquitination Cellular Response To Interferon-beta Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Negative Regulation Of TOR Signaling HULC Complex Response To Interferon-beta Regulation Of TORC1 Signaling Macromolecule Metabolic Process Postreplication Repair Skeletal Muscle Thin Filament Assembly DNA Repair Free Ubiquitin Chain Polymerization Positive Regulation Of Protein Modification Process Protein-containing Complex Regulation Of Protein Metabolic Process Leukocyte Chemotaxis Involved In Inflammatory Response DNA Damage Response Positive Regulation Of Post-translational Protein Modification	Protein Polyubiquitination Cellular Response To Leucine Starvation Protein K29-linked Ubiquitination Response To Reactive Oxygen Species Protein Ubiquitination Response To Stress Protein Modification By Small Protein Conjugation Protein K6-linked Ubiquitination Cellular Response To Nutrient Levels Ubiquitin-protein Transferase Activity Post-translational Protein Modification Response To Oxidative Stress Ubiquitin Protein Ligase Activity Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Protein Autoubiquitination Protein K63-linked Ubiquitination Proteolysis Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of TOR Signaling Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Response To Hydrogen Peroxide Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Apoptotic Process In Response To Mitochondrial Fragmentation Cellular Response To Stress Protein Modification Process Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Proteolysis Involved In Protein Catabolic Process Regulation Of TOR Signaling Response To UV NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Intracellular Signal Transduction Cellular Response To UV-C Thioredoxin-dependent Peroxiredoxin Activity Cellular Response To Starvation Metal Ion Binding Receptor Serine/threonine Kinase Binding Catabolic Process Peroxiredoxin Activity
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