CNMD and SOCS4

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		CNMD	SOCS4
Description		chondromodulin	suppressor of cytokine signaling 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endomembrane System Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Skeletal System Development Negative Regulation Of Endothelial Cell Proliferation Proteoglycan Metabolic Process Negative Regulation Of Angiogenesis Cell Differentiation Cartilage Development	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction
Pathways			RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs
Diseases
GWAS			Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817)
Interacting Genes		6 interacting genes: APPL2 C3orf52 FURIN HLA-DPA1 HSH2D SOCS4	11 interacting genes: CNMD EGFR LDHAL6B MDFIC NR4A1 PALS1 PLPP6 SPRY1 TEKT4 TNK2 VWF
Entrez ID		11061	122809
HPRD ID		05511	18084
Ensembl ID		ENSG00000136110	ENSG00000180008
Uniprot IDs		O75829	Q8WXH5
PDB IDs			2IZV
Enriched GO Terms of Interacting Partners?		Endosome Membrane Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Transforming Growth Factor Beta Receptor Signaling Pathway Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Receptor Catabolic Process Early Phagosome Membrane Cold Acclimation Regulation Of Cytokine Production Endosome Positive Regulation Of Proteolysis Viral Translation Viral Life Cycle Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cytokine Precursor Processing Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Nerve Growth Factor Binding Macropinosome Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Pinocytosis Regulation Of Immune Response MHC Class II Receptor Activity Signal Peptide Processing Heparan Sulfate Binding Adiponectin-activated Signaling Pathway Negative Regulation Of Mitochondrial Depolarization Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Diet Induced Thermogenesis Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Transforming Growth Factor Beta Production Early Phagosome Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of D-glucose Import Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity
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