DDX52 and AP4M1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DDX52	AP4M1
Description		DExD-box helicase 52	adaptor related protein complex 4 subunit mu 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane	Cytoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane AP-4 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Endosome Lumen Trans-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Protein Binding Protein Transmembrane Transporter Activity Protein Domain Specific Binding
	Biological Process	Maturation Of SSU-rRNA	Autophagosome Assembly Protein Targeting Protein Targeting To Lysosome Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Transmembrane Transport Golgi To Lysosome Transport Protein Localization To Basolateral Plasma Membrane
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Lysosome Vesicle Biogenesis
Drugs
Diseases			Cerebral palsy
GWAS		Ovarian cancer ( 23535730)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: AP4M1 HLCS MTNR1A PMP22 UTP23	16 interacting genes: ARF1 CACNG3 CD63 CHTF8 DDX52 FNTA GRID2 GRIN2A GRIN2B HOOK1 HOOK2 KRTAP5-2 LAMP2 TGOLN2 USP47 ZBTB22
Entrez ID		11056	9179
HPRD ID		09911	03803
Ensembl ID		ENSG00000278053	ENSG00000221838
Uniprot IDs		B3KM65 Q9Y2R4	C9JC87 C9JWL4 H7C0A0 O00189
PDB IDs		3DKP	3L81 4MDR
Enriched GO Terms of Interacting Partners?		Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Biotin Metabolic Process Response To Biotin Melatonin Receptor Activity Compact Myelin Protein Localization To Basolateral Plasma Membrane AP-4 Adaptor Complex Biotin Binding Small Ribosomal Subunit RRNA Binding Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Bleb Assembly Golgi To Lysosome Transport Clathrin Adaptor Complex Nuclear Lamina Golgi To Endosome Transport Myelin Assembly Hormone Binding Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)	Postsynaptic Density Membrane Ligand-gated Monoatomic Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential FHF Complex Synaptic Transmission, Glutamatergic Intracellular Protein Localization Platelet Dense Granule Membrane Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Protein Localization To Perinuclear Region Of Cytoplasm Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Calcium Ion Transmembrane Transport Regulation Of Synaptic Plasticity Excitatory Chemical Synaptic Transmission Cellular Localization Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Ion Transmembrane Transport Calcium Ion Transport HOPS Complex Modulation Of Chemical Synaptic Transmission Somatodendritic Compartment Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Transport Lysosomal Transport Inorganic Cation Transmembrane Transport Early Endosome To Late Endosome Transport Monoatomic Cation Transmembrane Transport AMPA Glutamate Receptor Complex Dynein Light Intermediate Chain Binding Positive Regulation Of Synaptic Transmission Late Endosome Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Inorganic Ion Transmembrane Transport Protein Localization To Postsynapse Transmembrane Transport Monoatomic Ion Channel Activity Vacuolar Transport Monoatomic Cation Transport Trans-Golgi Network Mitotic Cleavage Furrow Ingression Pigment Granule Maturation Peptide Pheromone Maturation Chaperone-mediated Autophagy Translocation Complex Establishment Of Protein Localization
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