CUTC and NADSYN1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CUTC	NADSYN1
Gene Name		cutC copper transporter	NAD synthetase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Copper Ion Binding	NAD+ Synthase (glutamine-hydrolyzing) Activity ATP Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds
	Biological Process	Copper Ion Transport Protein Tetramerization Copper Ion Homeostasis	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process NAD Biosynthetic Process NAD Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Obesity-related traits ( 23251661)	Vitamin D insufficiency ( 20541252) Vitamin D levels ( 20418485)
Protein-Protein Interactions		11 interactors: ASCC2 BCL6 CEP76 LNX1 NADSYN1 NIF3L1 NUDT18 PIM2 SDCBP SLC27A6 SPG21	3 interactors: CUTC MYO15B UPF1
Entrez ID		51076	55191
HPRD ID		13100	16309
Ensembl ID		ENSG00000119929	ENSG00000172890
Uniprot IDs		Q9NTM9	B3KUU4 Q6IA69
PDB IDs		3IWP
Enriched GO Terms of Interacting Partners?		GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Isotype Switching To IgE Isotypes Dihydrobiopterin Metabolic Process Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Extracellular Vesicular Exosome Assembly Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process	Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination Dosage Compensation Histone MRNA Metabolic Process Copper Ion Homeostasis Copper Ion Transport
Tagcloud ?			asip atm casp8 ccnd1 color cyp2r1 dark eye firstly gwas irf4 kaspar lately lentigines mc1r mx2 oca2 parp1 penetrance pigmentation predisposition rs12203592 rs1485993 rs1801516 rs3219090 slc45a2 spanish try works
Tagcloud (Difference) ?			asip atm casp8 ccnd1 color cyp2r1 dark eye firstly gwas irf4 kaspar lately lentigines mc1r mx2 oca2 parp1 penetrance pigmentation predisposition rs12203592 rs1485993 rs1801516 rs3219090 slc45a2 spanish try works
Tagcloud (Intersection) ?