CFHR3 and PRDX4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CFHR3	PRDX4
Description		complement factor H related 3	peroxiredoxin 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Complement Component C3b Binding Protein Binding	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Complement Activation	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways		Regulation of Complement cascade	Neutrophil degranulation
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23536807) Complement C3 and C4 levels ( 23028341) Complement factor H-related protein 3 levels ( 34260947) IgA nephropathy ( 25305756) Meningococcal disease ( 20694013) Nephropathy ( 21399633)
Interacting Genes		2 interacting genes: C3 PRDX4	27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		10878	10549
HPRD ID		05626	05935
Ensembl ID		ENSG00000116785	ENSG00000123131
Uniprot IDs		Q02985	Q13162 V9HW63
PDB IDs			2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Activation Of Membrane Attack Complex Complement-dependent Cytotoxicity Oviduct Epithelium Development Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Type IIa Hypersensitivity C5L2 Anaphylatoxin Chemotactic Receptor Binding Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Secretory Granule Lumen Regionalization Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Reactive Oxygen Species Metabolic Process Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Regulation Of Male Germ Cell Proliferation Protein Maturation Positive Regulation Of Complement Activation B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Regulation Of Germ Cell Proliferation Peroxiredoxin Activity Thioredoxin Peroxidase Activity Positive Regulation Of Hypersensitivity Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Apoptotic Cell Clearance Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing	Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin
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