CFHR3

Description		complement factor H related 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Component C3b Binding Protein Binding
	Biological Process	Complement Activation
Pathways		Regulation of Complement cascade
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23536807) Complement C3 and C4 levels ( 23028341) Complement factor H-related protein 3 levels ( 34260947) IgA nephropathy ( 25305756) Meningococcal disease ( 20694013) Nephropathy ( 21399633)
Novel Interacting Genes		1 novel interacting genes: TP53
Interacting Genes		2 interacting genes: C3 PRDX4
Entrez ID		10878
HPRD ID		05626
Ensembl ID		ENSG00000116785
Uniprot IDs		Q02985
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Activation Of Membrane Attack Complex Complement-dependent Cytotoxicity Oviduct Epithelium Development Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Type IIa Hypersensitivity C5L2 Anaphylatoxin Chemotactic Receptor Binding Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Secretory Granule Lumen Regionalization Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Reactive Oxygen Species Metabolic Process Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Regulation Of Male Germ Cell Proliferation Protein Maturation Positive Regulation Of Complement Activation B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Regulation Of Germ Cell Proliferation Peroxiredoxin Activity Thioredoxin Peroxidase Activity Positive Regulation Of Hypersensitivity Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Apoptotic Cell Clearance Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing
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