ASCL1 and MEF2D

Number of citations of the paper that reports this interaction (PMID 8900141)
16

Data Source:
BioGRID (two hybrid)

		ASCL1	MEF2D
Gene Name		achaete-scute family bHLH transcription factor 1	myocyte enhancer factor 2D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Neuronal Cell Body	Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding E-box Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Activating Transcription Factor Binding Histone Deacetylase Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Noradrenergic Neuron Development Noradrenergic Neuron Fate Commitment Transcription, DNA-templated Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Neuroblast Fate Determination Neuroblast Proliferation Response To Lithium Ion Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Association Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Vestibular Nucleus Development Cerebral Cortex GABAergic Interneuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Cerebral Cortex Development Neurogenesis Regulation Of Epithelial Cell Differentiation Response To Retinoic Acid Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Sympathetic Nervous System Development Neuron Fate Specification Musculoskeletal Movement, Spinal Reflex Action Response To Folic Acid Subpallium Neuron Fate Commitment Regulation Of Timing Of Subpallium Neuron Differentiation Olfactory Pit Development Lung Epithelial Cell Differentiation Ventral Spinal Cord Interneuron Fate Commitment Lung Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Carotid Body Glomus Cell Differentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Response To Epidermal Growth Factor Cellular Response To Magnetism Positive Regulation Of Neural Precursor Cell Proliferation	Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Transcription From RNA Polymerase II Promoter Apoptotic Process Nervous System Development Adult Heart Development Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Organelle biogenesis and maintenance CDO in myogenesis Myogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs
Diseases
GWAS		C-reactive protein ( 21300955)	Migraine ( 22683712)
Protein-Protein Interactions		8 interactors: BMP2 EP300 MEF2A MEF2C MEF2D NEUROG2 TCF4 UBQLN1	20 interactors: APP ASCL1 CABIN1 CARM1 CASP7 CDK6 COPS5 EP300 HDAC4 HDAC5 MAPK14 MAPK7 MEF2A MEF2C NFATC2 PRKACA PRMT5 SNCA SP1 YWHAQ
Entrez ID		429	4209
HPRD ID		00011	02810
Ensembl ID		ENSG00000139352	ENSG00000116604
Uniprot IDs		P50553	Q14814
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Muscle Structure Development Positive Regulation Of Protein Binding Chondrocyte Differentiation Muscle Organ Development Ossification Positive Regulation Of Transcription, DNA-templated Cell Fate Commitment Striated Muscle Tissue Development Positive Regulation Of Neuron Differentiation Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Binding Positive Regulation Of Cellular Biosynthetic Process Cardiovascular System Development Regulation Of Striated Muscle Tissue Development Positive Regulation Of Neurogenesis Skeletal Muscle Tissue Development Osteoblast Differentiation Positive Regulation Of Phosphatase Activity Regulation Of Protein Binding Primary Heart Field Specification Sinoatrial Valve Morphogenesis Regulation Of Synaptic Activity Cellular Response To Trichostatin A Skeletal Muscle Organ Development Heart Valve Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Heart Valve Development Organ Morphogenesis Positive Regulation Of Cell Development Positive Regulation Of Bone Mineralization Heart Development Endochondral Ossification Positive Regulation Of Biomineral Tissue Development Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Muscle Cell Fate Determination Cartilage Development Regulation Of Neuron Differentiation Neuroepithelial Cell Differentiation Positive Regulation Of Dephosphorylation Positive Regulation Of Cell Proliferation In Bone Marrow Bone Development Nervous System Development Connective Tissue Development Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Behavioral Fear Response	Regulation Of Protein Binding Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Cell Activation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Osteoblast Differentiation Signaling Negative Regulation Of Cellular Metabolic Process Cell Communication Immune System Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Defense Response Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Innate Immune Response Negative Regulation Of RNA Biosynthetic Process Regulation Of Ossification Cellular Response To Stimulus Regulation Of Striated Muscle Cell Differentiation Response To Growth Factor Regulation Of Signal Transduction Negative Regulation Of Gene Expression Gene Expression Apoptotic Process Transcription, DNA-templated Programmed Cell Death RNA Biosynthetic Process Organ Development Cell Death Death Regulation Of Signaling Notch Signaling Pathway Response To Organic Substance Cell Surface Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway
Tagcloud ?		axons chick circuitry commissure confirms cumulate describing differentiating follower gives highlighting hypothalamic hypothalamus mammillotegmental neglected neurogenesis nmtt notch ntpoc patterning postoptic proneural prosencephalon spatially temporally tracts ventral vertebrate vlt	blastula distinguished ectoderm ectopic embryo explants lie mef2a mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Difference) ?		axons chick circuitry commissure confirms cumulate describing differentiating follower gives highlighting hypothalamic hypothalamus mammillotegmental neglected neurogenesis nmtt notch ntpoc patterning postoptic proneural prosencephalon spatially temporally tracts ventral vertebrate vlt	blastula distinguished ectoderm ectopic embryo explants lie mef2a mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Intersection) ?