ASCL1 and NEUROG2

Number of citations of the paper that reports this interaction (PubMedID 8948587)
0

Data Source:
HPRD (in vitro, two hybrid)

		ASCL1	NEUROG2
Description		achaete-scute family bHLH transcription factor 1	neurogenin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Neuronal Cell Body RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Noradrenergic Neuron Development Noradrenergic Neuron Fate Commitment Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Pattern Specification Process Nervous System Development Neuroblast Fate Determination Neuroblast Proliferation Sensory Organ Development Heart Development Regulation Of Notch Signaling Pathway Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Association Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Vestibular Nucleus Development Oligodendrocyte Cell Fate Commitment Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Cerebral Cortex Development Neurogenesis Cell Differentiation Neuron Differentiation Regulation Of Epithelial Cell Differentiation Response To Retinoic Acid Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Neuron Fate Commitment Neuron Fate Specification Neuron Development Generation Of Neurons Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Musculoskeletal Movement, Spinal Reflex Action Response To Folic Acid Subpallium Neuron Fate Commitment Regulation Of Timing Of Subpallium Neuron Differentiation Olfactory Pit Development Lung Epithelial Cell Differentiation Ventral Spinal Cord Interneuron Fate Commitment Lung Neuroendocrine Cell Differentiation Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Carotid Body Glomus Cell Differentiation Adrenal Chromaffin Cell Differentiation Neural Precursor Cell Proliferation Sympathetic Ganglion Development Response To Epidermal Growth Factor Cellular Response To Magnetism GABAergic Neuron Differentiation Motor Neuron Migration Positive Regulation Of Neural Precursor Cell Proliferation	Nervous System Development Sensory Organ Development Cell Differentiation Forebrain Development Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Axon Development
Pathways		NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases		Congenital central hypoventilation syndrome (CCHS)
GWAS		C-reactive protein levels ( 21300955 30388399) Menopause (age at onset) ( 26414677) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Meat-related diet ( 32066663) Neuroblastoma (pediatric) ( 32599975) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: BMP2 EP300 HUNK MEF2A MEF2C MEF2D MTNR1A NEUROG2 RSPH1 TCF4 UBQLN1 UBQLN2 USP20	2 interacting genes: ASCL1 PFDN5
Entrez ID		429	63973
HPRD ID		00011	06976
Ensembl ID		ENSG00000139352	ENSG00000178403
Uniprot IDs		P50553	Q9H2A3
PDB IDs
Enriched GO Terms of Interacting Partners?		System Development Nervous System Development Protein Dimerization Activity Heart Development DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Cardiac Chamber Formation Positive Regulation Of Neuron Differentiation Autophagosome Assembly Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Autophagosome Organization Positive Regulation Of ERAD Pathway Regulation Of Cardiac Muscle Cell Differentiation Muscle Organ Development Positive Regulation Of RNA Metabolic Process Platelet Formation Regulation Of Autophagy Histone Deacetylase Binding Muscle Structure Development Regulation Of ERAD Pathway Regulation Of Smooth Muscle Cell Proliferation Muscle Tissue Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Vacuole Organization Cardiac Muscle Cell Differentiation Animal Organ Development Cellular Developmental Process Regulation Of Neuron Differentiation Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Bone Mineralization Positive Regulation Of Ossification Cell Differentiation Cardiocyte Differentiation Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Regulation Of Transport Transcription Regulator Complex Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity	Oligodendrocyte Cell Fate Commitment Regulation Of Timing Of Subpallium Neuron Differentiation Carotid Body Glomus Cell Differentiation Noradrenergic Neuron Fate Commitment Cellular Response To Magnetism Subpallium Neuron Fate Commitment Lung Neuroendocrine Cell Differentiation Neuroblast Fate Determination RNA Polymerase III Assembly RNA Polymerase I Assembly Response To Magnetism Musculoskeletal Movement, Spinal Reflex Action Adrenal Chromaffin Cell Differentiation Vestibular Nucleus Development RNA Polymerase II Core Complex Assembly Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Timing Of Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Olfactory Pit Development Stomach Neuroendocrine Cell Differentiation Oligodendrocyte Cell Fate Specification Cerebral Cortex GABAergic Interneuron Differentiation Noradrenergic Neuron Development Spinal Cord Oligodendrocyte Cell Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Glial Cell Fate Specification Prefoldin Complex Forebrain Neuron Fate Commitment Glial Cell Fate Commitment Sympathetic Ganglion Development Response To Folic Acid Spinal Cord Association Neuron Differentiation Peripheral Nervous System Neuron Development GABAergic Neuron Differentiation Musculoskeletal Movement Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Motor Neuron Migration Negative Regulation Of Amyloid Fibril Formation Enteroendocrine Cell Differentiation Ganglion Development Sympathetic Nervous System Development Regulation Of Amyloid Fibril Formation Reflex Neuroendocrine Cell Differentiation Generation Of Neurons Cerebral Cortex Neuron Differentiation Glandular Epithelial Cell Differentiation Lung Epithelial Cell Differentiation Oligodendrocyte Development
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