PLEKHG5

Description		pleckstrin homology and RhoGEF domain containing G5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Lamellipodium Endocytic Vesicle Axon Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Rho Protein Signal Transduction Endothelial Cell Chemotaxis Positive Regulation Of Canonical NF-kappaB Signal Transduction Endothelial Cell Migration Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RND3 GTPase cycle RND1 GTPase cycle
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Multiple sclerosis ( 24076602) QT interval ( 19305408)
Interacting Genes		1 interacting genes: AHCYL1
Entrez ID		57449
HPRD ID		11104
Ensembl ID		ENSG00000171680
Uniprot IDs		A0A804EMX3 O94827
PDB IDs
Enriched GO Terms of Interacting Partners?		S-adenosylmethionine Cycle Adenosylhomocysteinase Activity Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Monoatomic Anion Transport Regulation Of MRNA 3'-end Processing S-adenosylmethionine Metabolic Process Epithelial Fluid Transport Angiotensin-activated Signaling Pathway Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site One-carbon Metabolic Process Fluid Transport Protein Export From Nucleus Positive Regulation Of Sodium Ion Transport Enzyme Regulator Activity Transepithelial Transport Regulation Of Sodium Ion Transport Regulation Of Transmembrane Transporter Activity Membrane Docking Regulation Of Monoatomic Ion Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Nuclear Export Regulation Of MRNA Processing Response To Calcium Ion Intracellular Membrane-bounded Organelle Positive Regulation Of Monoatomic Ion Transport Nuclear Transport Nucleocytoplasmic Transport Sulfur Compound Metabolic Process
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