FAM46C and MVP

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		FAM46C	MVP
Gene Name		family with sequence similarity 46, member C	major vault protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nuclear Pore Cytoplasm Cytoskeleton Membrane Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function		Protein Binding Protein Kinase Binding Protein Phosphatase Binding
	Biological Process		Cell Proliferation Protein Transport Negative Regulation Of Signaling Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity Protein Activation Cascade
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AP2B1 DAZAP2 MVP PARK2 PLK4 RHOXF2 TRIP6	57 interactors: ADAMTSL4 AES BANP BZRAP1 C1orf94 CALCOCO2 CAMK2B CCDC36 CKAP4 CYTB DISC1 DLX2 EPHX2 ESR1 FAM154A FAM46C GIT2 GOLGA2 HP KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MKL1 NNT NOTCH2NL OBFC1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF111 SERTAD1 SKIL SLC2A4 TCF4 TFCP2 TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 VAC14 ZBTB32 ZMIZ2
Entrez ID		54855	9961
HPRD ID		13312	05475
Ensembl ID		ENSG00000183508	ENSG00000013364
Uniprot IDs		Q5VWP2	B4DP93 Q14764
PDB IDs			1Y7X
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Centriole Replication Positive Regulation Of Protein Linear Polyubiquitination ERBB Signaling Pathway Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Release Of Cytoplasmic Sequestered NF-kappaB Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Kinase Activity Positive Regulation Of Centrosome Duplication Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Negative Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Signaling Positive Regulation Of Mitochondrial Fission Negative Regulation Of Transferase Activity Regulation Of Mitochondrion Degradation Negative Regulation Of Protein Phosphorylation Dopamine Transport Regulation Of Centriole Replication Aggresome Assembly Negative Regulation Of Protein Autophosphorylation Regulation Of Mitochondrial Fission Neurotransmitter Uptake Norepinephrine Metabolic Process De Novo Centriole Assembly Negative Regulation Of Actin Filament Bundle Assembly Synaptic Transmission, Dopaminergic Regulation Of Signaling Negative Regulation Of Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Centriole Replication Positive Regulation Of Organelle Organization Zinc Ion Homeostasis Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Release Of Cytochrome C From Mitochondria Response To Manganese Ion	Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Response To Cytokine RNA Metabolic Process Defense Response Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Immune System Process Nitrogen Compound Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Positive Regulation Of Apoptotic Process Protein Localization To Nucleus Positive Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Intracellular Signal Transduction Cellular Metabolic Process Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		additionally characterize cheap comprehensive constructed customized del17p demonstrates easy fast frequency insight landscape literature majority mm mutated mutational myeloma panel practical prevalence profile provides published sequencing targeted tp53 untreated	afp bleomycin bronchogenic cap chance cisplatin cooperative crs cyclophosphamide doxorubicin eastern ecog efficacious entered est evaluable fluorouracil institution lethal mitomycin modest nscbc october oncology prs regimens shrinkage threatening vinblastine
Tagcloud (Difference) ?		additionally characterize cheap comprehensive constructed customized del17p demonstrates easy fast frequency insight landscape literature majority mm mutated mutational myeloma panel practical prevalence profile provides published sequencing targeted tp53 untreated	afp bleomycin bronchogenic cap chance cisplatin cooperative crs cyclophosphamide doxorubicin eastern ecog efficacious entered est evaluable fluorouracil institution lethal mitomycin modest nscbc october oncology prs regimens shrinkage threatening vinblastine
Tagcloud (Intersection) ?