AP4B1 and ZBTB14

		AP4B1	ZBTB14
Description		adaptor related protein complex 4 subunit beta 1	zinc finger and BTB domain containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Membrane Membrane Coat AP-4 Adaptor Complex Clathrin Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Cytoplasmic Side Of Trans-Golgi Network Transport Vesicle Membrane	Nucleus Nucleoplasm Nucleolus Cytosol Aggresome
	Molecular Function	Protein Binding Clathrin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Localization To Somatodendritic Compartment	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Kidney Development Regulation Of Immune System Process Heart Valve Development Cardiac Septum Development Negative Regulation Of DNA-templated Transcription Coronary Vasculature Development
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Cerebral palsy
GWAS		Alopecia areata ( 25608926) Breast cancer ( 23535729) Crohn's disease ( 28067908) Mean corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Cerebral amyloid deposition (PET imaging) ( 26252872) Lacunar stroke ( 33773637)
Interacting Genes		4 interacting genes: AP4E1 BUB1 BUB1B ZNF576	51 interacting genes: AP1M1 ATP5PO ATRIP BAZ2B BYSL C2orf68 CAPN6 CBX8 CDK16 CDKL3 CEP19 DDX6 EAF1 EIF1AD ENKD1 EPM2AIP1 FAM161A FAM90A1 GORASP2 INTS3 KAT5 MAD2L1BP MFAP1 MORF4L2 MRPL11 NAA10 NAA11 OGT PIN1 PNKP POLR2L PRMT1 RNASEH2B RNPS1 RPA1 RPA2 RPL9 RPS25 RPS7 SCNM1 SDCBP SNRPB2 SYT16 TCEANC TRIM55 TSTD2 TXN2 WNT9A ZBTB21 ZCCHC10 ZMAT2
Entrez ID		10717	7541
HPRD ID		06259	03674
Ensembl ID		ENSG00000134262	ENSG00000198081
Uniprot IDs		A0AAQ5BGI8 B1ALD1 B1ALD3 B3KSJ4 B4DTG3 Q9Y6B7	B2R850 O43829
PDB IDs		2MJ7
Enriched GO Terms of Interacting Partners?		Meiotic Sister Chromatid Cohesion, Centromeric Meiotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Cohesion Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Regulation Of Nuclear Division Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinetochore Mitotic Checkpoint Complex Kidney Development AP-4 Adaptor Complex Cargo Adaptor Activity Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Sarcomere Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Receptor Serine/threonine Kinase Binding Negative Regulation Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Atrial Cardiac Muscle Tissue Morphogenesis Telethonin Binding Negative Regulation Of Cell Cycle Phase Transition Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sarcomere Organization Regulation Of Chromosome Organization Positive Regulation Of Sister Chromatid Cohesion Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cell Cycle Process Adult Heart Development Heart Trabecula Formation Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Regulation Of Organelle Organization Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Regulation Of Sister Chromatid Cohesion Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Nucleoplasm Nucleus Macromolecule Metabolic Process Nucleic Acid Metabolic Process Regulation Of Double-strand Break Repair Regulation Of DNA Repair Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Site Of Double-strand Break Protein N-terminal-serine Acetyltransferase Activity Nucleotide-excision Repair Protein Binding DNA Repair Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Mismatch Repair NatA Complex Protein-N-terminal Amino-acid Acetyltransferase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Acetylation Positive Regulation Of Double-strand Break Repair Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination G-rich Strand Telomeric DNA Binding RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome N-terminal Protein Amino Acid Acetylation Clathrin Adaptor Complex Organelle Assembly RNA Splicing, Via Transesterification Reactions DNA Replication Factor A Complex Cytoplasmic Translation RNA Metabolic Process DNA Metabolic Process Regulation Of Cell Cycle Process
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