SPINT2 and HGFAC

Number of citations of the paper that reports this interaction (PubMedID 9346890)
0

Data Source:
HPRD (in vitro, in vivo)

		SPINT2	HGFAC
Description		serine peptidase inhibitor, Kunitz type 2	HGF activator
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Rough Endoplasmic Reticulum Cytosol
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation	Proteolysis Blood Coagulation Zymogen Activation
Pathways		MET Receptor Activation Signaling by MST1	MET Receptor Activation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31015462 31152163) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gamma glutamyl transferase levels ( 29403010 33339817) Height ( 31562340 29782485) Hepatocyte growth factor levels ( 25998175 27989323) Inflammatory bowel disease ( 26192919) Iron status biomarkers (total iron binding capacity) ( 33536631) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878 30578418) Serum total protein levels ( 29403010) Triglyceride levels ( 32203549 30698716 29403010 33339817 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)
Interacting Genes		6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4	10 interacting genes: APPBP2 CCHCR1 F2 GOLM1 HGF KLKB1 SLC30A2 SPINT1 SPINT2 VSIG1
Entrez ID		10653	3083
HPRD ID		05495	05184
Ensembl ID		ENSG00000167642	ENSG00000109758
Uniprot IDs		A0A140VJV6 O43291	D6RAR4 Q04756
PDB IDs		4U32	1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Hyaluronan Metabolic Process Endopeptidase Inhibitor Activity Glycosaminoglycan Metabolic Process Extracellular Region Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Macromolecule Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Peptidase Inhibitor Complex SUMO Ligase Complex Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Endolysosome Lumen Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Extracellular Exosome Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation	Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Fibrinolysis Cell Morphogenesis Negative Regulation Of Neural Precursor Cell Proliferation Cellular Response To BMP Stimulus Epithelial Cell Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Glial Cell Differentiation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Space Cellular Response To Growth Factor Stimulus Response To Growth Factor Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Endopeptidase Activity Factor XII Activation Tube Closure Serine-type Endopeptidase Inhibitor Activity Neural Tube Closure Regulation Of Neural Precursor Cell Proliferation Regulation Of Gliogenesis Coagulation Blood Coagulation Hemostasis Peptidase Inhibitor Activity Zinc Export Across Plasma Membrane Epithelial Cell Morphogenesis Involved In Placental Branching Serine-type Peptidase Activity Thrombospondin Receptor Activity Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Fibrinolysis Zinc Ion Import Into Lysosome Tube Formation Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Wound Healing Zinc:proton Antiporter Activity Proteolysis Growth Factor Activity Extracellular Region Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Wounding Regulation Of Branching Involved In Salivary Gland Morphogenesis Hepatocyte Growth Factor Receptor Signaling Pathway Vacuolar Transmembrane Transport
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