SPINT2 and ITIH3

Number of citations of the paper that reports this interaction (PMID 9359851)
1

Data Source:
HPRD (in vivo)

		SPINT2	ITIH3
Gene Name		serine peptidase inhibitor, Kunitz type, 2	inter-alpha-trypsin inhibitor heavy chain 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Integral Component Of Membrane	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Movement Of Cell Or Subcellular Component Negative Regulation Of Endopeptidase Activity	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process
Pathways
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 21926972) Immune reponse to smallpox (secreted IL-2) ( 22610502) Schizophrenia ( 21926974)
Protein-Protein Interactions		6 interactors: APP CTSB HGFAC ITIH2 ITIH3 SUMO4	2 interactors: EP300 SPINT2
Entrez ID		10653	3699
HPRD ID		05495	00891
Ensembl ID		ENSG00000167642	ENSG00000162267
Uniprot IDs		O43291	E7ET33 Q06033
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Hyaluronan Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Protein Metabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Catalytic Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Response To Thyroid Hormone Stimulus Extracellular Matrix Organization Extracellular Structure Organization Response To Thyroid Hormone Decidualization Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior	Histone H2B Acetylation N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Tubulin Deacetylation Positive Regulation By Host Of Viral Transcription N-terminal Protein Amino Acid Acetylation Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Interaction With Symbiont Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Viral Transcription Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Deacetylation Histone H4 Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Heat Positive Regulation Of Protein Binding Regulation Of Viral Transcription Positive Regulation Of Viral Process Positive Regulation Of Type I Interferon Production Regulation Of Cellular Protein Metabolic Process Somitogenesis Protein Stabilization Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process ER-nucleus Signaling Pathway Regulation Of Type I Interferon Production Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Response To Heat Histone Acetylation Signal Transduction By P53 Class Mediator Segmentation G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation Positive Regulation Of Binding Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Response To Unfolded Protein
Tagcloud ?		adhesion cd49b cd49d cd49e clonal defective downregulated dysfunctional hematopoiesis hematopoietic hepatocyte herein hgf hsc ineffective kunitz microenvironment msc mscs niche onto pathophysiology progenitors renewal sdf silenced stromal supporting underexpression	arranged borders ccaat consists cotransfection direction dnase duplication ebp ebpalpha ebpbeta exon exons footprinting h1 heavy hepg2 intron inversion itih1 itih4 kilobase opposite pair rounds shares transcribed trypsin
Tagcloud (Difference) ?		adhesion cd49b cd49d cd49e clonal defective downregulated dysfunctional hematopoiesis hematopoietic hepatocyte herein hgf hsc ineffective kunitz microenvironment msc mscs niche onto pathophysiology progenitors renewal sdf silenced stromal supporting underexpression	arranged borders ccaat consists cotransfection direction dnase duplication ebp ebpalpha ebpbeta exon exons footprinting h1 heavy hepg2 intron inversion itih1 itih4 kilobase opposite pair rounds shares transcribed trypsin
Tagcloud (Intersection) ?