SPINT2 and ITIH3

Number of citations of the paper that reports this interaction (PubMedID 9359851)
35

Data Source:
HPRD (in vivo)

		SPINT2	ITIH3
Description		serine peptidase inhibitor, Kunitz type 2	inter-alpha-trypsin inhibitor heavy chain 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Plasma Membrane Membrane	Extracellular Region Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation	Hyaluronan Metabolic Process
Pathways		MET Receptor Activation Signaling by MST1	Platelet degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 21926972 31043756) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Broad depression or bipolar disorder ( 30626913) Broad depression or schizophrenia ( 30626913) Cortical surface area (MOSTest) ( 32665545) Fasting insulin ( 34059833) Height ( 25282103) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-2) ( 22610502) Parkinson's disease ( 28892059) Red blood cell count ( 27863252 32888494) Schizophrenia ( 21926974 30285260 29483656 25056061 23974872) Smoking initiation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4	2 interacting genes: EP300 SPINT2
Entrez ID		10653	3699
HPRD ID		05495	00891
Ensembl ID		ENSG00000167642	ENSG00000162267
Uniprot IDs		A0A140VJV6 O43291	A0A994J439 E7ET33 Q06033
PDB IDs		4U32
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Hyaluronan Metabolic Process Endopeptidase Inhibitor Activity Glycosaminoglycan Metabolic Process Extracellular Region Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Macromolecule Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Peptidase Inhibitor Complex SUMO Ligase Complex Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Endolysosome Lumen Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Extracellular Exosome Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation	T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment Skeletal Muscle Tissue Development Regulation Of Cell Adhesion Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Striated Muscle Tissue Development Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Mitotic Cleavage Furrow Formation Regulation Of Neural Precursor Cell Proliferation Regulation Of Cell-cell Adhesion Regulation Of Generation Of Precursor Metabolites And Energy Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Alpha-beta T Cell Activation Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Positive Regulation Of Lymphocyte Differentiation Aortic Valve Formation Cell Fate Commitment Muscle Tissue Development Positive Regulation Of Vascular Associated Smooth Muscle Contraction Cell Morphogenesis Regulation Of T Cell Differentiation Establishment Or Maintenance Of Cell Polarity Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Leukocyte Differentiation Beta Selection Regulation Of Lymphocyte Differentiation N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Epithelial Cell Morphogenesis Involved In Placental Branching Anatomical Structure Morphogenesis
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