SPINT2 and ITIH2

Number of citations of the paper that reports this interaction (PMID 8601712)
3

Data Source:
BioGRID (pull down)

		SPINT2	ITIH2
Gene Name		serine peptidase inhibitor, Kunitz type, 2	inter-alpha-trypsin inhibitor heavy chain 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Integral Component Of Membrane	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Movement Of Cell Or Subcellular Component Negative Regulation Of Endopeptidase Activity	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process
Pathways
Drugs
Diseases
GWAS			Ovarian reserve ( 22116950)
Protein-Protein Interactions		6 interactors: APP CTSB HGFAC ITIH2 ITIH3 SUMO4	3 interactors: ATP5C1 FCER1A SPINT2
Entrez ID		10653	3698
HPRD ID		05495	00890
Ensembl ID		ENSG00000167642	ENSG00000151655
Uniprot IDs		O43291	P19823
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Hyaluronan Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Protein Metabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Catalytic Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Response To Thyroid Hormone Stimulus Extracellular Matrix Organization Extracellular Structure Organization Response To Thyroid Hormone Decidualization Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior	Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Serotonin Secretion Serotonin Transport Positive Regulation Of Hypersensitivity Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Mast Cell Activation Mitochondrial ATP Synthesis Coupled Proton Transport Monovalent Inorganic Cation Transport Positive Regulation Of Regulated Secretory Pathway Leukotriene Biosynthetic Process Monoamine Transport Regulation Of Mast Cell Degranulation Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Calcium-mediated Signaling ATP Synthesis Coupled Proton Transport Leukotriene Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Activation Of JUN Kinase Activity Regulation Of Regulated Secretory Pathway ATP Biosynthetic Process Regulation Of Calcium-mediated Signaling Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Cation Transport Positive Regulation Of Exocytosis Positive Regulation Of Cytokine Biosynthetic Process Ammonium Transport Positive Regulation Of JUN Kinase Activity Oxidative Phosphorylation Regulation Of Acute Inflammatory Response Purine Ribonucleoside Monophosphate Biosynthetic Process Regulation Of JUN Kinase Activity Nucleoside Triphosphate Biosynthetic Process JNK Cascade Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Inflammatory Response Icosanoid Metabolic Process
Tagcloud ?		adhesion cd49b cd49d cd49e clonal defective downregulated dysfunctional hematopoiesis hematopoietic hepatocyte herein hgf hsc ineffective kunitz microenvironment msc mscs niche onto pathophysiology progenitors renewal sdf silenced stromal supporting underexpression	5mg breakdown bred conceptus corn cypionate ecm endometrial endometrium expresses gestation gilts glycocalyx hyaluronic il6 le linker lumenal microvilli pge pig snap surgically tnfaip6 trt trypsin uterine uterus
Tagcloud (Difference) ?		adhesion cd49b cd49d cd49e clonal defective downregulated dysfunctional hematopoiesis hematopoietic hepatocyte herein hgf hsc ineffective kunitz microenvironment msc mscs niche onto pathophysiology progenitors renewal sdf silenced stromal supporting underexpression	5mg breakdown bred conceptus corn cypionate ecm endometrial endometrium expresses gestation gilts glycocalyx hyaluronic il6 le linker lumenal microvilli pge pig snap surgically tnfaip6 trt trypsin uterine uterus
Tagcloud (Intersection) ?