NLRP7

Description		NLR family pyrin domain containing 7
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GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Nucleotide Binding ATP Binding Aspartic-type Endopeptidase Inhibitor Activity Interleukin-1 Binding Identical Protein Binding Caspase Binding
	Biological Process	Negative Regulation Of Protein Processing Negative Regulation Of Interleukin-1 Beta Production Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways
Drugs
Diseases		Recurrent hydatidiform moles (RHM); Familial biparental hydatidiform
GWAS		Inflammatory bowel disease ( 23128233)
Interacting Genes		2 interacting genes: FAF1 STAMBP
Entrez ID		199713
HPRD ID		10112
Ensembl ID		ENSG00000167634
Uniprot IDs		A0A0G2JNK3 K7ERG0 Q8WX94
PDB IDs		2KM6
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Hippocampal Neuron Apoptotic Process Ooplasm Fas Signaling Pathway Negative Regulation Of Hippocampal Neuron Apoptotic Process Regulation Of Hippocampal Neuron Apoptotic Process CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Metal-dependent Deubiquitinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intracellular Signal Transduction K63-linked Deubiquitinase Activity Protein Kinase Regulator Activity Cell Death Apoptotic Process Protein K63-linked Deubiquitination Deubiquitinase Activity Programmed Cell Death Negative Regulation Of Ras Protein Signal Transduction NF-kappaB Binding Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Mitotic Cytokinesis Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Communication Regulation Of Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cleavage Furrow Proteolysis Negative Regulation Of Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Heat Shock Protein Binding Positive Regulation Of DNA Replication Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Cytoskeleton-dependent Cytokinesis ERAD Pathway Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Binding Protein Modification By Small Protein Removal Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of DNA Replication Metallopeptidase Activity Positive Regulation Of Apoptotic Signaling Pathway
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