HEXIM1 and RN7SK

Number of citations of the paper that reports this interaction (PubMedID 29845934)
80

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology)

		HEXIM1	RN7SK
Description		HEXIM P-TEFb complex subunit 1	RNA component of 7SK nuclear ribonucleoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm 7SK SnRNP	7SK SnRNP
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding P-TEFb Complex Binding Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Immune System Process Heart Development Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation By RNA Polymerase II Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription Elongation By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474 31959851) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Insomnia ( 32332799) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)	Staphylococcus aureus nasal carriage (intermittent) ( 26569114)
Interacting Genes		13 interacting genes: CCNT1 CCNT2 CDK9 CEBPA EGFR ESR1 HEXIM2 PPM1G RELA RN7SK TERF1 TERF2 UBE2O	7 interacting genes: CCNT1 CDK9 HEXIM1 HMGA1 LARP7 MEPCE PPM1G
Entrez ID		10614	125050
HPRD ID		09544
Ensembl ID		ENSG00000186834	ENSG00000202198
Uniprot IDs		O94992
PDB IDs		2GD7 3S9G
Enriched GO Terms of Interacting Partners?		7SK SnRNA Binding Chromatin Binding Cyclin/CDK Positive Transcription Elongation Factor Complex Nucleobase-containing Compound Biosynthetic Process Transcription Coactivator Binding SnRNA Binding Host-mediated Activation Of Viral Transcription DNA-templated Transcription P-TEFb Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Host-mediated Activation Of Viral Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Nucleoplasm Shelterin Complex Positive Regulation Of Transcription Elongation By RNA Polymerase II Ankyrin Repeat Binding Telomerase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Protein Kinase Binding Negative Regulation Of Macromolecule Metabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Host-mediated Perturbation Of Viral Process Regulation Of MiRNA Transcription G-rich Strand Telomeric DNA Binding Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Telomeric Loop Disassembly Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Telomere Capping Regulation Of MiRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Xenobiotic Stimulus Transcription By RNA Polymerase II Nucleus Negative Regulation Of Biosynthetic Process Host-mediated Perturbation Of Symbiont Process	7SK SnRNA Binding SnRNA Binding 7SK SnRNP Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation P-TEFb Complex Positive Regulation Of SnRNA Transcription By RNA Polymerase II SnRNA Modification Cyclin/CDK Positive Transcription Elongation Factor Complex Positive Regulation Of Protein Localization To Cajal Body Negative Regulation Of Viral Transcription Host-mediated Activation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Host-mediated Perturbation Of Viral Transcription Negative Regulation Of RNA Metabolic Process SnRNA Processing Host-mediated Activation Of Viral Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription SnRNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Host-mediated Perturbation Of Viral Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Viral Process U6 2'-O-snRNA Methylation RNA 5'-gamma-phosphate Methyltransferase Activity RNA Methylation Positive Regulation Of Protein Localization Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Chromatin Binding Host-mediated Perturbation Of Symbiont Process Nucleoplasm Macromolecule Methylation Modulation Of Process Of Another Organism
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