HEXIM1 and CCNT2

Number of citations of the paper that reports this interaction (PMID 12832472)
91

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, in vitro, two hybrid)

		HEXIM1	CCNT2
Gene Name		hexamethylene bis-acetamide inducible 1	cyclin T2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding	Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Heart Development Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Division
Pathways			Loss of Function of TGFBR2 in Cancer RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Systolic blood pressure ( 19430483)
Protein-Protein Interactions		9 interactors: CCNT1 CCNT2 CDK9 EGFR ESR1 RELA RN7SK TERF1 TERF2	6 interactors: BRD4 CDK9 HEXIM1 PKN1 RB1 SUPT5H
Entrez ID		10614	905
HPRD ID		09544	04839
Ensembl ID		ENSG00000186834	ENSG00000082258
Uniprot IDs		O94992	B4DH21 O60583
PDB IDs		2GD7 3S9G	2IVX
Enriched GO Terms of Interacting Partners?		Regulation Of DNA Replication Response To Cobalamin Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Telomeric Loop Formation Age-dependent Telomere Shortening Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication Cellular Response To Growth Factor Stimulus Telomere Maintenance Via Telomere Shortening Response To Growth Factor DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression DNA-templated Transcription, Elongation Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Replicative Cell Aging Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of DNA Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Telomere Maintenance Cellular Response To Estradiol Stimulus Viral Process RNA-dependent DNA Replication Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cell Cycle Response To Organic Substance Regulation Of Chromosome Organization Cellular Response To Estrogen Stimulus Telomere Maintenance Via Telomere Lengthening	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cell Cycle Viral Process Chromatin Modification RNA Metabolic Process Chromatin Remodeling Gene Expression Chromatin Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Nucleobase-containing Compound Metabolic Process Regulation Of Protein Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Replication Fork Arrest Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		aml besides bisacetamide carry competing elongation focus hdm2 hexamethylene immunodeficiency importantly inducible minute noteworthy npm npmc nucleophosmin p53 partners polymerase prevented regulators tat tefb third transactivation tumorigenesis ubiquitinate ubiquitination
Tagcloud (Difference) ?		aml besides bisacetamide carry competing elongation focus hdm2 hexamethylene immunodeficiency importantly inducible minute noteworthy npm npmc nucleophosmin p53 partners polymerase prevented regulators tat tefb third transactivation tumorigenesis ubiquitinate ubiquitination
Tagcloud (Intersection) ?