HEXIM1 and HEXIM2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		HEXIM1	HEXIM2
Description		HEXIM P-TEFb complex subunit 1	HEXIM P-TEFb complex subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm 7SK SnRNP	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding P-TEFb Complex Binding Transcription Regulator Inhibitor Activity	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Immune System Process Heart Development Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation By RNA Polymerase II Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474 31959851) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Insomnia ( 32332799) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)	Asthma ( 31619474 31959851) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		13 interacting genes: CCNT1 CCNT2 CDK9 CEBPA EGFR ESR1 HEXIM2 PPM1G RELA RN7SK TERF1 TERF2 UBE2O	47 interacting genes: ADAMTSL4 AP2M1 CACNB2 CCDC33 CCNT1 CDK9 CFP CTIF DBF4B DRC4 EGFL7 FAM161A GATA1 HEXIM1 HOXA1 HSF2BP IHO1 KPNA3 KPRP KRTAP13-3 LNX1 MEOX2 PICK1 PIM1 PIN1 PRDM14 PSMA1 RNPS1 SAXO1 SDCBP SPRED1 SPRY1 SPRY2 TADA3 TERF1 TERF2 TLE5 TNFAIP1 TRIM14 YPEL3 ZNF250 ZNF426 ZNF500 ZNF558 ZNF655 ZNF699 ZNF789
Entrez ID		10614	124790
HPRD ID		09544	08129
Ensembl ID		ENSG00000186834	ENSG00000168517
Uniprot IDs		O94992	Q96MH2
PDB IDs		2GD7 3S9G
Enriched GO Terms of Interacting Partners?		7SK SnRNA Binding Chromatin Binding Cyclin/CDK Positive Transcription Elongation Factor Complex Nucleobase-containing Compound Biosynthetic Process Transcription Coactivator Binding SnRNA Binding Host-mediated Activation Of Viral Transcription DNA-templated Transcription P-TEFb Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Host-mediated Activation Of Viral Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Nucleoplasm Shelterin Complex Positive Regulation Of Transcription Elongation By RNA Polymerase II Ankyrin Repeat Binding Telomerase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Protein Kinase Binding Negative Regulation Of Macromolecule Metabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Host-mediated Perturbation Of Viral Process Regulation Of MiRNA Transcription G-rich Strand Telomeric DNA Binding Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Telomeric Loop Disassembly Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Telomere Capping Regulation Of MiRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Xenobiotic Stimulus Transcription By RNA Polymerase II Nucleus Negative Regulation Of Biosynthetic Process Host-mediated Perturbation Of Symbiont Process	Negative Regulation Of Lens Fiber Cell Differentiation 7SK SnRNA Binding Regulation Of Lens Fiber Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process P-TEFb Complex SnRNA Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Shelterin Complex Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Telomerase Activity Bud Elongation Involved In Lung Branching Protein Binding Nucleus Cyclin/CDK Positive Transcription Elongation Factor Complex Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Epithelial To Mesenchymal Transition Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Negative Regulation Of Epithelial To Mesenchymal Transition DNA Binding Regulation Of Cellular Response To Growth Factor Stimulus G-rich Strand Telomeric DNA Binding Negative Regulation Of Epithelial Cell Differentiation Telomeric Loop Disassembly Regulation Of Neurotrophin TRK Receptor Signaling Pathway Telomere Capping Regulation Of Cell Cycle Branch Elongation Of An Epithelium DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Viral Transcription Protein Serine/threonine Kinase Activator Activity Host-mediated Activation Of Viral Transcription Axis Elongation Regulation Of Receptor Internalization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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