LRRC8E and GPSM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRRC8E	GPSM2
Description		leucine rich repeat containing 8 VRAC subunit E	G protein signaling modulator 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex	Spindle Pole Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lateral Plasma Membrane Protein-containing Complex Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding	Nucleotide Binding G-protein Alpha-subunit Binding GDP-dissociation Inhibitor Activity Protein Binding Protein Domain Specific Binding GTPase Regulator Activity Identical Protein Binding Dynein Complex Binding
	Biological Process	Monoatomic Ion Transport Cell Volume Homeostasis Aspartate Transmembrane Transport Monoatomic Ion Transmembrane Transport Cellular Response To Osmotic Stress Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane	Establishment Of Mitotic Spindle Orientation Mitotic Spindle Organization G Protein-coupled Receptor Signaling Pathway Response To Light Intensity Cell Division Maintenance Of Centrosome Location Regulation Of Mitotic Spindle Organization Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly
Pathways		Miscellaneous transport and binding events	G alpha (i) signalling events
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS			Fat distribution (HIV) ( 21897333)
Interacting Genes		7 interacting genes: FBXO7 GPSM2 LNX2 NUTM1 SAMD4B TRIM2 TRIM3	17 interacting genes: AGR2 ARHGEF40 DLG4 FXR1 FXR2 GAS2L1 GLIS2 GNAI1 GNAI2 GNAI3 GNAO1 HRAS INSC LRRC8E NRIP1 NUMA1 WHRN
Entrez ID		80131	29899
HPRD ID		08670	06609
Ensembl ID		ENSG00000171017	ENSG00000121957
Uniprot IDs		Q6NSJ5	B4DIF1 P81274
PDB IDs			3SF4 4WND 4WNE 4WNF 4WNG 5A6C 6HC2
Enriched GO Terms of Interacting Partners?		Ubiquitin-protein Transferase Activity Macromolecule Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteasomal Protein Catabolic Process Neural Precursor Cell Proliferation Lateral Cell Cortex Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Lewy Body Core Cell Cortex Region Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Maintenance Of Centrosome Location Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly Post-translational Protein Modification Regulation Of Protein Localization To Cell Cortex	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Regulation Of Long-term Neuronal Synaptic Plasticity Heterotrimeric G-protein Complex Regulation Of Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Adenylate Cyclase Regulator Activity Modulation Of Chemical Synaptic Transmission GTPase Activity Ciliary Basal Body Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Periphery GTP Binding Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Long-term Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Regulation Of Synaptic Plasticity G Protein Activity G Protein-coupled Receptor Binding GDP Binding Positive Regulation Of Protein Localization To Cell Periphery Cell Division Regulation Of Biological Quality Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Translation Regulator Activity Regulation Of Cell Communication Regulation Of Signaling G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Protein Localization Cytoskeletal Anchor Activity Cytoplasm Microtubule Plus-end Dentate Gyrus Development Neuron Projection Negative Regulation Of Secretion By Cell Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Secretion P2Y1 Nucleotide Receptor Binding Negative Regulation Of Transport Cell Cortex Negative Regulation Of Insulin Secretion Positive Regulation Of Metabolic Process Regulation Of Mitotic Spindle Organization Midbody Positive Regulation Of Protein Localization Negative Regulation Of Peptide Secretion
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