LRRC8E and SAMD4B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRRC8E	SAMD4B
Description		leucine rich repeat containing 8 VRAC subunit E	sterile alpha motif domain containing 4B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex	P-body Nucleus Cytoplasm Cytosol
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding	RNA Binding MRNA Binding Protein Binding Translation Repressor Activity
	Biological Process	Monoatomic Ion Transport Cell Volume Homeostasis Aspartate Transmembrane Transport Monoatomic Ion Transmembrane Transport Cellular Response To Osmotic Stress Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane	Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Translation Regulation Of MRNA Stability
Pathways		Miscellaneous transport and binding events
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS			Alanine aminotransferase levels ( 33339817) Obesity-related traits ( 23251661)
Interacting Genes		7 interacting genes: FBXO7 GPSM2 LNX2 NUTM1 SAMD4B TRIM2 TRIM3	8 interacting genes: BCL2L10 CCDC179 CFTR LRRC8E NUTM1 RSRC2 USP53 YWHAG
Entrez ID		80131	55095
HPRD ID		08670	10960
Ensembl ID		ENSG00000171017	ENSG00000179134
Uniprot IDs		Q6NSJ5	M0QZ22 Q5PRF9 Q66K25 Q8IXP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-protein Transferase Activity Macromolecule Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteasomal Protein Catabolic Process Neural Precursor Cell Proliferation Lateral Cell Cortex Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Lewy Body Core Cell Cortex Region Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Maintenance Of Centrosome Location Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly Post-translational Protein Modification Regulation Of Protein Localization To Cell Cortex
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