USP16 and CCT8

		USP16	CCT8
Description		ubiquitin specific peptidase 16	chaperonin containing TCP1 subunit 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Zona Pellucida Receptor Complex Extracellular Region Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cilium Secretory Granule Lumen Azurophil Granule Lumen Cell Projection Cell Body Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Ribosomal Small Subunit Binding Ubiquitin Binding Metal Ion Binding Histone H2A Deubiquitinase Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis DNA Damage Response Regulation Of Gene Expression Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Positive Regulation Of Ribosome Biogenesis Mitotic Nuclear Division	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Ub-specific processing proteases	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		23 interacting genes: CALM1 CDK1 DNM1L EXOSC10 FAU FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4C16 ISG15 LINC02381 PAX6 PLK1 PTOV1 SATB1 TTK UBC UBD XRN2 ZEB2	5 interacting genes: ACTB APP CEBPA OGT PTEN
Entrez ID		10600	10694
HPRD ID		06881	10816
Ensembl ID		ENSG00000156256	ENSG00000156261
Uniprot IDs		Q9Y5T5	P50990 Q7Z759
PDB IDs		2I50 8WG5	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome Chromatin Remodeling Protein Tag Activity Chromosome Regulation Of Chromosome Organization Chromatin Organization Post-translational Protein Modification Protein Ubiquitination Protein Localization To Organelle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Heterodimerization Activity Female Meiosis Chromosome Segregation Regulation Of Sister Chromatid Segregation Spindle Microtubule Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Segregation G2/M Transition Of Mitotic Cell Cycle Heterochromatin Formation Protein Localization To Chromatin Nucleoplasm Nucleus Mitotic Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Mitotic Nuclear Membrane Disassembly Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Telomerase RNA Localization To Cajal Body Protein Localization To Kinetochore Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Meiotic Chromosome Segregation Nuclear Membrane Disassembly Negative Regulation Of Biosynthetic Process Membrane Disassembly Negative Regulation Of Chromosome Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Gene Expression Positive Regulation Of Protein Localization To Nucleus	Positive Regulation Of Proteolysis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Proteolysis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Axonogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Excitatory Postsynaptic Potential Developmental Maturation Microglial Cell Activation Reproductive Behavior Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Protein-containing Complex Neuron Projection Morphogenesis Regulation Of Cell Junction Assembly Neuron Projection Organization Learning Or Memory Cell Projection Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Organization Cognition Regulation Of Glycolytic Process Response To Stress Modulation Of Excitatory Postsynaptic Potential Synapse Negative Regulation Of Developmental Process Macrophage Activation Positive Regulation Of Metabolic Process Regulation Of Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding
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