SMC2 and ERP44

		SMC2	ERP44
Description		structural maintenance of chromosomes 2	endoplasmic reticulum protein 44
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GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Specific Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	Nuclear Division Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Chromosome Organization Cell Division Kinetochore Organization Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation	Protein Folding Response To Unfolded Protein Glycoprotein Metabolic Process Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	Neutrophil degranulation
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203 33549134) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Oily fish consumption ( 32066663) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Pork consumption ( 32066663) Sensorimotor dexterity ( 31596458)	Preeclampsia ( 23551011)
Interacting Genes		11 interacting genes: ABCC5 CDC42 CEBPA DISC1 DNMT3B GULP1 LIG4 NCAPD2 PTEN SMC4 TRAF3IP1	3 interacting genes: ERO1A ERO1B ITPR1
Entrez ID		10592	23071
HPRD ID		09277	10290
Ensembl ID		ENSG00000136824	ENSG00000023318
Uniprot IDs		A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1	A0A384MEE7 Q9BS26
PDB IDs		4U4P	2R2J 5GU6 5GU7 5HQP 5XWM
Enriched GO Terms of Interacting Partners?		Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Organelle Organization Dendritic Spine Morphogenesis Response To Lithium Ion Cellular Response To Lithium Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Organization Mitotic Chromosome Condensation Regulation Of Chromosome Condensation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Embryonic Heart Tube Development Phagocytosis, Engulfment Positive Regulation Of Chromosome Segregation Dendritic Spine Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Separation Condensed Chromosome Positive Regulation Of Organelle Organization Response To Electrical Stimulus Chromosome Condensation Positive Regulation Of Proteolysis Neuron Projection Organization Postsynapse Organization System Development Regulation Of Cell-substrate Adhesion Ciliary Base Macrophage Differentiation Membrane Invagination Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency Regulation Of Chromosome Organization Negative Regulation Of Synaptic Vesicle Clustering Chromosome Organization Involved In Meiotic Cell Cycle Condensed Nuclear Chromosome Carbohydrate Derivative Transmembrane Transporter Activity CGMP Transport Macromolecule Transmembrane Transporter Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Process Mononuclear Cell Differentiation GBD Domain Binding Storage Vacuole Positive Regulation Of Cell Cycle	Calcineurin Complex Thiol Oxidase Activity Protein Folding In Endoplasmic Reticulum Protein-disulfide Reductase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis FAD Binding Endoplasmic Reticulum Membrane Sphingolipid Floppase Activity Release Of Sequestered Calcium Ion Into Cytosol Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Negative Regulation Of Sequestering Of Calcium Ion Response To Vitamin B3 Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Cytoskeletal Calyx Endoplasmic Reticulum-Golgi Intermediate Compartment Organization
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