ERLIN1 and AGR3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		ERLIN1	AGR3
Description		ER lipid raft associated 1	anterior gradient 3, protein disulphide isomerase family member
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Membrane Raft	Endoplasmic Reticulum
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Ubiquitin Protein Ligase Binding	Dystroglycan Binding Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process SREBP Signaling Pathway ERAD Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301 33339817) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for body mass index ( 34021172)	Coffee consumption ( 29367735 31959922) Cutaneous malignant melanoma ( 26237428 32341527) Cutaneous squamous cell carcinoma ( 32041948) Diffusing capacity of carbon monoxide ( 30694715) Lung cancer in ever smokers ( 28604730) Melanoma ( 28212542) Refractive error ( 32231278) Residual cognition ( 28441426) Rosacea symptom severity ( 29771307) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)
Interacting Genes		8 interacting genes: AGR3 BNIP2 FA2H FILNC1 RBFA SEC22A SEC23A VMA12	35 interacting genes: AKT1 AP1B1 APC ASB10 BCAR3 CASP8 CATSPER1 CD46 CGRRF1 CNNM3 DAG1 DESI1 EDA2R ERLIN1 ESR2 FXYD3 KRTAP11-1 LIME1 LSM1 LYPD3 MMGT1 NRM NTAQ1 NUP62 PDZK1IP1 PRAF2 PTPN1 SGTA SGTB SPINT1 TGFB1 TIMMDC1 TMEM14B UBQLN1 UBQLN2
Entrez ID		10613	155465
HPRD ID		08502	16545
Ensembl ID		ENSG00000107566	ENSG00000173467
Uniprot IDs		O75477	Q8TD06
PDB IDs			3PH9
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sebaceous Gland Cell Differentiation 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Glucosylceramide Biosynthetic Process Fatty Acid 2-hydroxylase Activity Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Central Nervous System Myelin Maintenance Membrane Organization COPII-coated Vesicle Budding Galactosylceramide Biosynthetic Process Galactosylceramide Metabolic Process Glucosylceramide Metabolic Process Vacuolar Proton-transporting V-type ATPase Complex Assembly Proton-transporting V-type ATPase Complex Assembly Peripheral Nervous System Myelin Maintenance Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activator Activity COPII Vesicle Coat Golgi Vesicle Transport Myelin Maintenance Plasma Membrane Raft Organization Glycosylceramide Metabolic Process COPI-coated Vesicle Membrane Lysosomal Protein Catabolic Process Oxysterol Binding Vacuolar Proton-transporting V-type ATPase Complex Cellular Response To Increased Oxygen Levels Protein Catabolic Process In The Vacuole Dystroglycan Binding COPII-coated Vesicle Cargo Loading	Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Regulation Of ERAD Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Glial Cell Differentiation ERAD Pathway Positive Regulation Of Protein Catabolic Process Membrane Positive Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Response To Fluid Shear Stress Regulation Of Protein Catabolic Process Proteolysis Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization Cellular Response To Decreased Oxygen Levels Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Catabolic Process Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Protein Localization To Centrosome Cellular Response To Oxygen Levels Positive Regulation Of Gliogenesis Regulation Of Sodium Ion Transport Regulation Of Glial Cell Differentiation Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Migration Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Tail-anchored Membrane Protein Insertion Into ER Membrane Lamellipodium Regulation Of Metal Ion Transport Laminin Binding Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Response To Laminar Fluid Shear Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Catabolic Process Autophagosome Assembly Positive Regulation Of Endothelial Cell Apoptotic Process
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