ERLIN1

Description		ER lipid raft associated 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Membrane Raft
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Ubiquitin Protein Ligase Binding
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process SREBP Signaling Pathway ERAD Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301 33339817) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		8 interacting genes: AGR3 BNIP2 FA2H FILNC1 RBFA SEC22A SEC23A VMA12
Entrez ID		10613
HPRD ID		08502
Ensembl ID		ENSG00000107566
Uniprot IDs		O75477
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sebaceous Gland Cell Differentiation 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Glucosylceramide Biosynthetic Process Fatty Acid 2-hydroxylase Activity Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Central Nervous System Myelin Maintenance Membrane Organization COPII-coated Vesicle Budding Galactosylceramide Biosynthetic Process Galactosylceramide Metabolic Process Glucosylceramide Metabolic Process Vacuolar Proton-transporting V-type ATPase Complex Assembly Proton-transporting V-type ATPase Complex Assembly Peripheral Nervous System Myelin Maintenance Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activator Activity COPII Vesicle Coat Golgi Vesicle Transport Myelin Maintenance Plasma Membrane Raft Organization Glycosylceramide Metabolic Process COPI-coated Vesicle Membrane Lysosomal Protein Catabolic Process Oxysterol Binding Vacuolar Proton-transporting V-type ATPase Complex Cellular Response To Increased Oxygen Levels Protein Catabolic Process In The Vacuole Dystroglycan Binding COPII-coated Vesicle Cargo Loading
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