SLC9A6 and CFTR

Number of citations of the paper that reports this interaction (PMID 11707463)
46

Data Source:
HPRD (in vivo)

		SLC9A6	CFTR
Gene Name		solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Late Endosome Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Dendrite Cytoplasmic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle Axon Terminus Axonal Spine Synapse Recycling Endosome Membrane	Cytoplasm Early Endosome Plasma Membrane Microvillus Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Endoplasmic Reticulum Sec Complex Early Endosome Membrane Chloride Channel Complex Protein Complex Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Sodium:proton Antiporter Activity	ATP-binding And Phosphorylation-dependent Chloride Channel Activity Chloride Channel Activity Channel-conductance-controlling ATPase Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding
	Biological Process	Transport Ion Transport Regulation Of PH Brain-derived Neurotrophic Factor Receptor Signaling Pathway Sodium Ion Transmembrane Transport Axon Extension Neuron Projection Morphogenesis Synapse Organization Regulation Of Neurotrophin TRK Receptor Signaling Pathway Transmembrane Transport Dendritic Spine Development Dendrite Extension Hydrogen Ion Transmembrane Transport	Cholesterol Biosynthetic Process Transport Water Transport Respiratory Gaseous Exchange Bicarbonate Transport Iodide Transport Cholesterol Transport Transepithelial Chloride Transport Lung Development Cellular Response To Hormone Stimulus Response To Cytokine Vasodilation Response To Drug Response To Peptide Hormone Response To Estrogen Positive Regulation Of Vasodilation Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity
Pathways		Sodium/Proton exchangers Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport	ABC-family proteins mediated transport
Drugs			Bumetanide Glyburide Ibuprofen Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine Crofelemer Ivacaftor
Diseases
GWAS			Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		1 interactors: CFTR	28 interactors: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STX1A UBC UBE2I
Entrez ID		10479	1080
HPRD ID		02208	03883
Ensembl ID		ENSG00000198689	ENSG00000001626
Uniprot IDs		Q92581	P13569
PDB IDs			1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Voltage-gated Chloride Channel Activity Regulation Of Chloride Transport Iodide Transport Transepithelial Chloride Transport Transepithelial Transport Intracellular PH Elevation Sperm Capacitation Bicarbonate Transport Positive Regulation Of Vasodilation Vasodilation Cholesterol Biosynthetic Process Membrane Hyperpolarization Water Transport Sterol Biosynthetic Process Regulation Of Intracellular PH Regulation Of Vasodilation Regulation Of Cellular PH Fluid Transport Cellular Response To CAMP Positive Regulation Of Ion Transmembrane Transporter Activity Respiratory Gaseous Exchange Positive Regulation Of Transporter Activity Sterol Transport Cholesterol Transport Regulation Of PH Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport Cholesterol Metabolic Process Steroid Biosynthetic Process Response To CAMP Sterol Metabolic Process Chloride Transport Spermatid Development Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Maturation Spermatid Differentiation Response To Organophosphorus Response To Purine-containing Compound Positive Regulation Of Ion Transport Response To Estrogen Lung Development Steroid Metabolic Process Germ Cell Development Respiratory Tube Development Inorganic Anion Transport Regulation Of Membrane Potential	Chemical Homeostasis Ion Homeostasis Transport Homeostatic Process Negative Regulation Of Glucose Import Activation Of Phospholipase C Activity Regulation Of Protein Transport Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Ion Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Catalytic Activity Cellular Localization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of PH Positive Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Ion Transport Regulation Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Lyase Activity Regulation Of Phospholipase Activity Regulation Of Insulin Secretion Positive Regulation Of Lipase Activity Histone H3-T6 Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Transport Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Synaptic Vesicle Transport Regulation Of Platelet Activation Negative Regulation Of Intracellular Signal Transduction Anion Transport Cellular Cation Homeostasis Peptidyl-serine Phosphorylation Inorganic Anion Transport Cellular Homeostasis Regulation Of Hormone Secretion Regulation Of Signaling Negative Regulation Of Nucleotide Metabolic Process Regulation Of Wound Healing
Tagcloud ?		angelman cask cdkl5 christianson cockayne crebbp deceleration dysmorphologic ep300 epilepsies fascinating formerly foxg1 grouping hindbrain hopkins mecp2 microcephaly neurobehavioral oculo ophthalmologic phenotyping pitt realms rett rubinstein taybi tcf4 warburg	aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies
Tagcloud (Difference) ?		angelman cask cdkl5 christianson cockayne crebbp deceleration dysmorphologic ep300 epilepsies fascinating formerly foxg1 grouping hindbrain hopkins mecp2 microcephaly neurobehavioral oculo ophthalmologic phenotyping pitt realms rett rubinstein taybi tcf4 warburg	aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies
Tagcloud (Intersection) ?