CDX1 and SOX2

Number of citations of the paper that reports this interaction (PMID 15143193)
19

Data Source:
BioGRID (pull down)

		CDX1	SOX2
Gene Name		caudal type homeobox 1	SRY (sex determining region Y)-box 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Transcription Factor Complex
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Organ Morphogenesis Anterior/posterior Pattern Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Positive Regulation Of Neuroblast Proliferation Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Response To Wounding Regulation Of Gene Expression Glial Cell Fate Commitment Forebrain Neuron Differentiation Pituitary Gland Development Adenohypophysis Development Cerebral Cortex Development Positive Regulation Of Cell-cell Adhesion Male Genitalia Development Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Olfactory Placode Formation Response To Retinoic Acid Somatic Stem Cell Maintenance Tissue Regeneration Inner Ear Morphogenesis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Tongue Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Pigment Biosynthetic Process Lung Alveolus Development Neuron Fate Commitment Inner Ear Development Diencephalon Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Detection Of Mechanical Stimulus Involved In Equilibrioception Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye Epithelial Tube Branching Involved In Lung Morphogenesis Response To Growth Factor Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance
Pathways			Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CEBPA LEF1 SOX2	9 interactors: ALX4 CDX1 FZR1 NR5A1 POU2F1 POU5F1 SETD7 SUMO1 XPO1
Entrez ID		1044	6657
HPRD ID		02849	08921
Ensembl ID		ENSG00000113722	ENSG00000181449
Uniprot IDs		P47902	P48431
PDB IDs			1O4X 2LE4
Enriched GO Terms of Interacting Partners?		Respiratory System Development Tongue Development Embryonic Organ Development Gland Development Reproductive Structure Development Reproductive System Development Sensory Organ Development Forebrain Neuron Differentiation Tube Development Developmental Process Involved In Reproduction Forebrain Generation Of Neurons Negative Regulation Of Transcription From RNA Polymerase II Promoter Diencephalon Development Response To Lipid Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Myeloid Leukocyte Differentiation Embryonic Placenta Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Negative Regulation Of Transcription, DNA-templated Osteoblast Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Canonical Wnt Signaling Pathway Embryo Development Detection Of Mechanical Stimulus Involved In Equilibrioception Single Organism Reproductive Process Reproductive Process Glial Cell Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Inner Ear Development Negative Regulation Of Biosynthetic Process Gastrulation Placenta Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Ossification Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Branching Morphogenesis Of An Epithelial Tube Pallium Development Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Apoptotic Process In Bone Marrow Regulation Of Cell Proliferation Central Nervous System Neuron Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Gene Expression Ear Development	Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Protein Localization To Nucleus Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Developmental Induction Transcription From RNA Polymerase II Promoter Tissue Development Organ Development Regulation Of Protein Catabolic Process RNA Metabolic Process Anatomical Structure Development Lens Development In Camera-type Eye Cellular Macromolecule Biosynthetic Process Protein Localization To Organelle Palate Development Macromolecule Biosynthetic Process Developmental Process Ribosomal Small Subunit Export From Nucleus Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway BMP Signaling Pathway Involved In Heart Induction Negative Regulation Of Gene Silencing By MiRNA Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Methylation-dependent Chromatin Silencing Primary Sex Determination PML Body Organization Cardiac Cell Fate Determination Embryonic Morphogenesis System Development BMP Signaling Pathway Involved In Heart Development
Tagcloud ?		aberrent differentiation discussed disruption embryonal f9 gamma gap43 idea impaired null overexpressing poorly ra rar rars redundancy reexpressing reexpression replace rescue responsive restored retinoic stra4 stra6 subsets supporting trans	adipogenic af afmsc afmscs amniotic cd326 cd90 chaperones chondrogenic classes eighteen f fibroblast fluid hc1 hc2 multipotent osteogenic phenotypes pin predominant preparations proteasomes proteomic regardless regenerative slight spots ssea
Tagcloud (Difference) ?		aberrent differentiation discussed disruption embryonal f9 gamma gap43 idea impaired null overexpressing poorly ra rar rars redundancy reexpressing reexpression replace rescue responsive restored retinoic stra4 stra6 subsets supporting trans	adipogenic af afmsc afmscs amniotic cd326 cd90 chaperones chondrogenic classes eighteen f fibroblast fluid hc1 hc2 multipotent osteogenic phenotypes pin predominant preparations proteasomes proteomic regardless regenerative slight spots ssea
Tagcloud (Intersection) ?