ENPP4

Description		ectonucleotide pyrophosphatase/phosphodiesterase 4
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GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Hydrolase Activity Metal Ion Binding Bis(5'-adenosyl)-triphosphatase Activity
	Biological Process	Blood Coagulation Hemostasis Positive Regulation Of Blood Coagulation Purine Ribonucleoside Catabolic Process
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma trimethylamine N-oxide levels ( 28439531) Platelet distribution width ( 32888494)
Interacting Genes		2 interacting genes: TMBIM6 TMEM147
Entrez ID		22875
HPRD ID		16862
Ensembl ID		ENSG00000001561
Uniprot IDs		Q9Y6X5
PDB IDs		4LQY 4LR2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcium Ion Transport Into Cytosol Endoribonuclease Inhibitor Activity IRE1-mediated Unfolded Protein Response Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein Localization To Nuclear Inner Membrane Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Negative Regulation Of Cellular Response To Hypoxia Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Immunoglobulin Production Protein Localization To Nuclear Envelope Cellular Response To Unfolded Protein Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To L-glutamate Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Topologically Incorrect Protein Negative Regulation Of RNA Splicing Protein Insertion Into ER Membrane Endoplasmic Reticulum Membrane Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Calcium Ion Transport Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Protein Insertion Into Membrane Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Ribosome Binding Regulation Of Immunoglobulin Production Response To Unfolded Protein Calcium Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Monoatomic Ion Transport
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