PARVG and CSF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PARVG	CSF3
Description		parvin gamma	colony stimulating factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Anchoring Junction	Extracellular Region Extracellular Space Lysosomal Lumen Endocytic Vesicle Lumen
	Molecular Function	Actin Binding Protein Binding	Signaling Receptor Binding Cytokine Activity Granulocyte Colony-stimulating Factor Receptor Binding Growth Factor Activity Enzyme Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Cell Projection Assembly Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape	Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Granulocyte Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Response To Ethanol Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Regulation Of Actin Filament Organization
Pathways			Other interleukin signaling Interleukin-10 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling
Drugs
Diseases
GWAS		Fasting glucose ( 33381925) Metabolite levels ( 23823483) Survival in colon cancer ( 25866641)	Asthma ( 31619474) Bipolar disorder ( 31043756) Composite immunoglobulin trait (IgA x IgG) ( 28628107) Creatine kinase levels ( 29403010) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mitochondrial DNA copy number ( 30704525) Myeloid white cell count ( 27863252) Neutrophil count ( 20172861 32888494 27863252 25096241) Neutrophil percentage of white cells ( 27863252 32888494) Rheumatoid arthritis ( 24390342 30423114) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 20139978 32888494 29403010 28158719 27863252 21738480) White blood cell count (neutrophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		33 interacting genes: ALX4 ANTKMT APP CDHR3 CDSN CFAP53 CSF3 DDIT4L FOSL1 GADD45A HOMEZ ILK KCTD7 KLHL32 LHX3 LNX2 MEOX1 MEOX2 NBPF22P NBPF6 NDEL1 PDLIM7 POLR2G POU6F2 REL SERTAD2 TLE5 TRIB2 TRIM54 TSGA10IP USHBP1 ZNF426 ZNF677	6 interacting genes: CSF3R ELANE PARVG S100A6 S100P TBX3
Entrez ID		64098	1440
HPRD ID		16285	00736
Ensembl ID		ENSG00000138964	ENSG00000108342
Uniprot IDs		Q9HBI0	P09919 Q6FH65 Q8N4W3
PDB IDs			1CD9 1GNC 1PGR 1RHG 2D9Q 5GW9 5ZO6
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Somite Specification DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin HMG Box Domain Binding Positive Regulation Of RNA Metabolic Process Segment Specification Somite Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process	Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle G1/S Phase Transition Y Chromosome Positive Regulation Of Heterochromatin Formation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Cellular Senescence Granulocyte Colony-stimulating Factor Binding Cytokine Binding Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Negative Regulation Of Chemotaxis Neutrophil-mediated Killing Of Fungus Positive Regulation Of Interleukin-8 Production Protein Homodimerization Activity Quinone Catabolic Process Melatonin Binding Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Dihydronicotinamide Riboside Quinone Reductase Activity Resveratrol Binding Calcium-dependent Protein Binding Follicle-stimulating Hormone Secretion Atrioventricular Bundle Cell Differentiation Limbic System Development Ureteric Peristalsis Hepatoblast Differentiation Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Regulation Of Interleukin-8 Production Antibacterial Peptide Biosynthetic Process NAD(P)H Dehydrogenase (quinone) Activity Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Mammary Placode Formation His-Purkinje System Cell Differentiation Specification Of Animal Organ Position
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