SNAI2 and FBXO28

Number of citations of the paper that reports this interaction (PubMedID 37596321)
47

Data Source:
BioGRID (enzymatic study)

		SNAI2	FBXO28
Description		snail family transcriptional repressor 2	F-box protein 28
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromosome, Centromeric Region Kinetochore Chromosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Migration Involved In Endocardial Cushion Formation Chromatin Organization Regulation Of DNA-templated Transcription Substrate-dependent Cell Migration Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Notch Signaling Pathway Sensory Perception Of Sound Response To Radiation Epithelial Cell Migration Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Vitamin D Biosynthetic Process Neural Crest Cell Development Positive Regulation Of Cell Migration Negative Regulation Of Chondrocyte Differentiation Regulation Of Chemokine Production Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Cell Adhesion Mediated By Integrin Desmosome Disassembly Pigmentation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Endothelial Cell Migration Positive Regulation Of Fat Cell Differentiation Regulation Of Osteoblast Differentiation Mesenchymal Cell Differentiation White Fat Cell Differentiation Roof Of Mouth Development Epithelium Development Cartilage Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Hematopoietic Stem Cell Proliferation Cellular Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Polyubiquitination
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription Negative Regulation of CDH1 Gene Transcription Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases		Waardenburg syndrome (WS) Piebaldism
GWAS		Hip index ( 34021172)	Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		14 interacting genes: APP CABP2 CREBBP CSNK2A1 FBXO28 FBXO45 PIAS1 PIAS2 PIAS3 PIAS4 SAT1 TRIM23 UBE2I ZNF76	21 interacting genes: AGGF1 CSNK2A1 CTNNA3 EMILIN1 EMILIN3 EXOC7 GCC1 GK GOLGA2 GOLGA6L9 PFKFB4 PLEKHF2 PMF1 PSMC3 SDCBP2 SNAI2 SPAG5 STX1B TOP2A TRAF2 VHL
Entrez ID		6591	23219
HPRD ID		03689	12367
Ensembl ID		ENSG00000019549	ENSG00000143756
Uniprot IDs		O43623	Q9NVF7
PDB IDs
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity SUMO Ligase Activity Protein Sumoylation Post-translational Protein Modification Presynaptic Cytosol Postsynaptic Cytosol PML Body Protein Modification By Small Protein Conjugation Transcription Coregulator Activity Positive Regulation Of Protein Sumoylation Regulation Of Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Protein Metabolic Process Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Negative Regulation Of Biosynthetic Process Double-strand Break Repair Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription By RNA Polymerase II Transferase Complex Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Metal Ion Binding Positive Regulation Of Post-translational Protein Modification Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Recombination Recombinational Repair Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Double-strand Break Repair Zinc Ion Binding Negative Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium
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